Sequence Browser (O00219-2)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
553

Isoforms (From UniProt)

Isoform
Remark
Ref
O00219-1
O00219-2  
No experimental confirmation available.
VSP_042022
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Protein Information (From UniProt)

Protein:
Hyaluronan synthase 3
Other Names:
Hyaluronate synthase 3, Hyaluronic acid synthase 3
Primary Accession:
O00219
Other Accessions:
A8K5T5, Q8WTZ0, Q9NYP0
Gene :
HAS3*
Organism :
Human
Entry Name :
HYAS3_HUMAN
Length :
553
Mass (Da) :
62,998
Last modified :
23-Jan-2008
Version :
v3
Isoforms :
2 
Structures :
Experimental 0 | Phyre prediction 1
Function : Show Hide

Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction (By similarity).