Sequence Browser (O14763-3)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
If the whole structure is coloured grey in '3D Structure Viewer' panel, please click the icon - on the top left corner of the viewer.
(If nothing changes then 'Sequence ↔ Structure' mapping may be unavailable).
1
440

Isoforms (From UniProt)

Isoform
Remark
Ref
O14763-3  
May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
VSP_039125
O14763-1
May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
O14763-2
May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
VSP_006490
Click on Isoform of interest to be redirected to the corresponding page

3D Structure Viewer - JSMol  

To analyse the structural impact of your missense variant:

  • Select the corresponding experimental/modelled structure from the "Available Structures" Panel.
  • Right-click on the target structure and download it.
  • Go to our web server Missense3D to analyse structural impact.

    • Go to Missense3D

Protein Information (From UniProt)

Protein:
Tumor necrosis factor receptor superfamily member 10B
Other Names:
Death receptor 5, TNF-related apoptosis-inducing ligand receptor 2
Primary Accession:
O14763
Other Accessions:
O14720, O15508, O15517, O15531, Q6UXM8, Q7Z360, Q9BVE0
Gene :
TNFRSF10B*, synonyms (DR5, KILLER, TRAILR2, TRICK2, ZTNFR9)
Organism :
Human
Entry Name :
TR10B_HUMAN
Length :
440
Mass (Da) :
47,878
Last modified :
30-Jan-2010
Version :
v2
Isoforms :
3 
Structures :
Experimental 0 | Phyre prediction 2
Function : Show Hide

Receptor for the cytotoxic ligand TNFSF10/TRAIL (PubMed:10549288). The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappa-B. Essential for ER stress-induced apoptosis.