Sequence Browser (O60673-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
3130

Isoforms (From UniProt)

Isoform
Remark
Ref
O60673-1  
O60673-2
VSP_024121
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
Missing
1 - 78
sequence variant
S → T
389
sequence variant
S → G
633
sequence variant
R → Q
962
sequence variant
S → L
1220
sequence variant
T → P
1284
sequence variant
Q → H
1309
sequence variant
Q → P
1469
sequence variant
S → L
1576
sequence variant
S → T
1724
sequence variant
D → H
1812
sequence variant
R → H
1970
sequence variant
I → M
2075
sequence variant
R → Q
2762
mutagenesis site
D → N
2614
sequence conflict
E → Q
237
sequence variant
Q → H
231
sequence variant
Q → P
397
sequence variant
M → T
693
sequence variant
Y → C
1156
sequence variant
T → I
1224
sequence variant
S → T
1302
sequence variant
P → T
1339
sequence variant
K → E
1540
sequence variant
D → N
1713
sequence variant
P → S
1791
sequence variant
G → R
1923
sequence variant
E → V
2015
sequence variant
S → T
2607
sequence variant
V → I
3064
mutagenesis site
D → N
2783

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
DNA polymerase zeta catalytic subunit
Other Names:
Protein reversionless 3-like
Primary Accession:
O60673
Other Accessions:
O43214, Q5TC33
Gene :
REV3L*, synonyms (POLZ, REV3)
Organism :
Human
Entry Name :
REV3L_HUMAN
Length :
3,130
Mass (Da) :
352,776
Last modified :
03-Jan-2007
Version :
v2
Isoforms :
2 
Variants :
31 
Interactions :
1 
Structures :
Experimental 6 | Phyre prediction 0
Function : Show Hide

Catalytic subunit of the DNA polymerase zeta complex, an error-prone polymerase specialized in translesion DNA synthesis (TLS). Lacks an intrinsic 3'-5' exonuclease activity and thus has no proofreading function.

Interactions (From UniProt)

With
Entry
IntAct
Exp
MAD2L2
Q9UI95
EBI-2871302, EBI-77889
5