Sequence Browser (O75081-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
653

Isoforms (From UniProt)

Isoform
Remark
Ref
O75081-1  
O75081-2
VSP_028620 VSP_028624
O75081-4
No experimental confirmation available.
VSP_028621
O75081-5
No experimental confirmation available.
VSP_028622 VSP_028623
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
Missing
1 - 61
splice variant
A → GKPALAAAGAPALCTPGQADARPVLGPA
51
splice variant
Missing
102 - 126
sequence variant
E → G
429
splice variant
APVDRKAKASAMPDSPAEVKTQPRSTPPSMPPPPPAASQGATRPPSFTPHTHREDGPATLPHGRFHGCLKWSMVCLL → V
51 - 127
splice variant
Missing
52 - 653
sequence variant
R → H
306
sequence variant
E → K
518
mutagenesis site
V → P,A
494
sequence conflict
T → S
295
sequence variant
A → V
534
sequence conflict
F → L
231
sequence conflict
D → E
305
sequence conflict
L → V
420
sequence conflict
R → P
370
sequence conflict
A → D
542

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Protein CBFA2T3
Other Names:
MTG8-related protein 2, Myeloid translocation gene on chromosome 16 protein, Zinc finger MYND domain-containing protein 4
Primary Accession:
O75081
Other Accessions:
D3DX78, O60615, O60616, O60617, O75082, O75107, O75108, Q0P5Z6, Q6P5W6
Gene :
CBFA2T3*, synonyms (MTG16, MTGR2, ZMYND4)
Organism :
Human
Entry Name :
MTG16_HUMAN
Length :
653
Mass (Da) :
71,192
Last modified :
23-Jan-2007
Version :
v2
Isoforms :
4 
Variants :
16 
Interactions :
2 
Structures :
Experimental 0 | Phyre prediction 6
Function : Show Hide

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Reduces the protein levels and stability of the transcriptinal regulator HIF1A; interacts with EGLN1 and promotes the HIF1A prolyl hydroxylation-dependent ubiquitination and proteasomal degradation pathway (PubMed:25974097). Contributes to inhibition of glycolysis and stimulation of mitochondrial respiration by down-regulating the expression of glycolytic genes including PFKFB3, PFKFB4, PDK1, PFKP, LDHA and HK1 which are direct targets of HIF1A (PubMed:23840896, PubMed:25974097). Regulates the proliferation and the differentiation of erythroid progenitors by repressing the expression of TAL1 target genes (By similarity). Plays a role in granulocyte differentiation (PubMed:15231665).

Isoform 2 functions as an A-kinase-anchoring protein (PubMed:11823486).

Interactions (From UniProt)

With
Entry
IntAct
Exp
PLXNA3
P51805
EBI-1190217, EBI-7135904
2
ZNF652
Q9Y2D9
EBI-1190217, EBI-1190229
2