To analyse the structural impact of your missense variant:
- Select the corresponding experimental/modelled structure from the "Available Structures" Panel.
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- Go to our web server Missense3D to analyse structural impact.
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Protein:
Other Names:
Molecule interacting with CasL protein 2
Primary Accession:
Other Accessions:
B4DGZ0, B7Z849, D3DQW5, G3XAC8, Q5KTR3, Q5KTR4, Q7Z3A8
Gene
:
MICAL2*, synonyms (KIAA0750, MICAL2PV1, MICAL2PV2)
Organism
:
Human
Entry
Name :
Length
:
1,124
Mass (Da)
:
126,689
Last
modified :
01-Jan-1999
Version
:
v1
Isoforms
:
6
Variants
:
21
Interactions
:
0
Structures
:
Experimental 1 | Phyre prediction 5
Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin to form methionine-sulfoxide, resulting in actin filament disassembly and preventing repolymerization. In the absence of actin, it also functions as a NADPH oxidase producing H(2)O(2) (By similarity). Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.