Sequence Browser (O95936-4)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
686

Isoforms (From UniProt)

Isoform
Remark
Ref
O95936-1
O95936-2
No experimental confirmation available. Dubious isoform produced through aberrant splice sites.
VSP_042161 VSP_042162
O95936-4  
No experimental confirmation available.
VSP_042162
O95936-3
No experimental confirmation available.
VSP_054801 VSP_042162
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3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Eomesodermin homolog
Other Names:
T-box brain protein 2
Primary Accession:
O95936
Other Accessions:
B7Z4I2, B7ZA51, G3XAI5, Q8TAZ2, Q9UPM7
Gene :
EOMES*, synonyms (TBR2)
Organism :
Human
Entry Name :
EOMES_HUMAN
Length :
686
Mass (Da) :
72,732
Last modified :
05-Jan-2009
Version :
v3
Isoforms :
4 
Structures :
Experimental 0 | Phyre prediction 1
Function : Show Hide

Functions as a transcriptional activator playing a crucial role during development. Functions in trophoblast differentiation and later in gastrulation, regulating both mesoderm delamination and endoderm specification. Plays a role in brain development being required for the specification and the proliferation of the intermediate progenitor cells and their progeny in the cerebral cortex. Also involved in the differentiation of CD8+ T-cells during immune response regulating the expression of lytic effector genes.