Sequence Browser (P01241-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
217

Isoforms (From UniProt)

Isoform
Remark
Ref
P01241-5
No experimental confirmation available.
VSP_045642
P01241-2
VSP_006200
P01241-1  
P01241-3
VSP_006201
P01241-4
VSP_006202
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
Missing
58 - 97
splice variant
Missing
111 - 148
sequence variant
T → A
3
sequence variant
D → N
37
sequence variant
T → I
53
splice variant
Missing
58 - 72
splice variant
Missing
117 - 162
sequence variant
L → P
16
sequence variant
R → C
42
sequence variant
K → R
67
sequence variant
C → S
79
sequence variant
E → K
100
sequence variant
S → C
105
sequence variant
S → C
134
sequence variant
V → I
136
sequence variant
T → A
201
sequence variant
R → H
209
sequence conflict
M → S
40
sequence variant
N → D
73
sequence variant
S → F
97
sequence variant
R → C
103
sequence variant
Q → L
117
sequence variant
S → R
134
sequence variant
D → G
138
sequence variant
I → M
205
sequence conflict
L → P
35

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Somatotropin
Other Names:
Growth hormone, Growth hormone 1, Pituitary growth hormone
Primary Accession:
P01241
Other Accessions:
A6NEF6, Q14405, Q16631, Q5EB53, Q9HBZ1, Q9UMJ7, Q9UNL5
Gene :
GH1*
Organism :
Human
Entry Name :
SOMA_HUMAN
Length :
217
Mass (Da) :
24,847
Last modified :
01-Jan-1992
Version :
v2
Isoforms :
5 
Variants :
26 
Interactions :
1 
Structures :
Experimental 9 | Phyre prediction 2
Function : Show Hide

Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues.

Interactions (From UniProt)

With
Entry
IntAct
Exp
GHR
P10912
EBI-1026046, EBI-286316
3