Sequence Browser (P08253-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
660

Isoforms (From UniProt)

Isoform
Remark
Ref
P08253-2
Induced by oxidative stress.
VSP_044631
P08253-3
No experimental confirmation available.
VSP_045704
P08253-1  
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
Missing
1 - 76
sequence variant
R → H
101
sequence variant
A → T
228
sequence variant
E → K
404
sequence variant
T → M
498
sequence variant
S → I
644
sequence conflict
S → G
546
splice variant
MEALMARGALTGPLRALCLLGCLLSHAAAAPSPIIKFPGDVAPKTDKELAV → M
1 - 51
sequence variant
D → Y
210
sequence variant
Missing
400
sequence variant
A → V
447
sequence variant
V → L
621
sequence conflict
F → S
235
sequence conflict
D → G
618

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
72 kDa type IV collagenase
Other Names:
72 kDa gelatinase, Gelatinase A, Matrix metalloproteinase-2, TBE-1
Primary Accession:
P08253
Other Accessions:
B2R6U1, B4DWH3, E9PE45, Q9UCJ8
Gene :
MMP2*, synonyms (CLG4A)
Organism :
Human
Entry Name :
MMP2_HUMAN
Length :
660
Mass (Da) :
73,882
Last modified :
01-Jan-1991
Version :
v2
Isoforms :
3 
Variants :
14 
Interactions :
3 
Structures :
Experimental 12 | Phyre prediction 2
Function : Show Hide

Ubiquitinous metalloproteinase that is involved in diverse functions such as remodeling of the vasculature, angiogenesis, tissue repair, tumor invasion, inflammation, and atherosclerotic plaque rupture. As well as degrading extracellular matrix proteins, can also act on several nonmatrix proteins such as big endothelial 1 and beta-type CGRP promoting vasoconstriction. Also cleaves KISS at a Gly-|-Leu bond. Appears to have a role in myocardial cell death pathways. Contributes to myocardial oxidative stress by regulating the activity of GSK3beta. Cleaves GSK3beta in vitro. Involved in the formation of the fibrovascular tissues in association with MMP14.

PEX, the C-terminal non-catalytic fragment of MMP2, posseses anti-angiogenic and anti-tumor properties and inhibits cell migration and cell adhesion to FGF2 and vitronectin. Ligand for integrinv/beta3 on the surface of blood vessels.

Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro-inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.

Interactions (From UniProt)

With
Entry
IntAct
Exp
COL5A1
P20908
EBI-1033518, EBI-2464511
2
SCUBE3
Q8IX30
EBI-1033518, EBI-4479975
2
PCSK9
Q8NBP7
EBI-1033518, EBI-7539251
4