Sequence Browser (P24386-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
653

Isoforms (From UniProt)

Isoform
Remark
Ref
P24386-2
No experimental confirmation available.
VSP_042817 VSP_042818
P24386-1  
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Variants (From UniProt)

Type
Variation
Position
splice variant
SQDLHE → RSTLLL
105 - 110
splice variant
Missing
111 - 653
sequence variant
Q → L
471
sequence variant
H → R
507
sequence variant
L → P
550
mutagenesis site
F → L
282
mutagenesis site
V → F
290
sequence conflict
AS → RA
625 - 626

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Rab proteins geranylgeranyltransferase component A 1
Other Names:
Choroideremia protein, Rab escort protein 1, TCD protein
Primary Accession:
P24386
Other Accessions:
A1L4D2, O43732
Gene :
CHM*, synonyms (REP1, TCD)
Organism :
Human
Entry Name :
RAE1_HUMAN
Length :
653
Mass (Da) :
73,476
Last modified :
06-Jan-2002
Version :
v3
Isoforms :
2 
Variants :
8 
Interactions :
0 
Structures :
Experimental 0 | Phyre prediction 1
Function : Show Hide

Substrate-binding subunit of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B composed of RABGGTA and RABGGTB, and remains bound to it after the geranylgeranyl transfer reaction. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Besides, a pre-formed complex consisting of CHM and the Rab GGTase dimer (RGGT or component B) can bind to and prenylate Rab proteins; this alternative pathway is proposed to be the predominant pathway for Rab protein geranylgeranylation.

Interactions (From UniProt)

No interactions reported for this protein.