Sequence Browser (P26010-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
798

Isoforms (From UniProt)

Isoform
Remark
Ref
P26010-1  
P26010-2
VSP_002753
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Variants (From UniProt)

Type
Variation
Position
splice variant
Missing
501 - 648
mutagenesis site
D → A
159
sequence variant
H → Y
672
sequence conflict
W → A
34

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Integrin beta-7
Other Names:
Gut homing receptor beta subunit
Primary Accession:
P26010
Other Accessions:
Q9UCP7, Q9UCS7
Gene :
ITGB7*
Organism :
Human
Entry Name :
ITB7_HUMAN
Length :
798
Mass (Da) :
86,903
Last modified :
01-Jan-1992
Version :
v1
Isoforms :
2 
Variants :
4 
Interactions :
2 
Structures :
Experimental 3 | Phyre prediction 3
Function : Show Hide

Integrin alpha-4/beta-7 (Peyer patches-specific homing receptor LPAM-1) is an adhesion molecule that mediates lymphocyte migration and homing to gut-associated lymphoid tissue (GALT). Integrin alpha-4/beta-7 interacts with the cell surface adhesion molecules MADCAM1 which is normally expressed by the vascular endothelium of the gastrointestinal tract. Interacts also with VCAM1 and fibronectin, an extracellular matrix component. It recognizes one or more domains within the alternatively spliced CS-1 region of fibronectin. Interactions involves the tripeptide L-D-T in MADCAM1, and L-D-V in fibronectin. Binds to HIV-1 gp120, thereby allowing the virus to enter GALT, which is thought to be the major trigger of AIDS disease. Interaction would involve a tripeptide L-D-I in HIV-1 gp120. Integrin alpha-E/beta-7 (HML-1) is a receptor for E-cadherin.

Interactions (From UniProt)

With
Entry
IntAct
Exp
ITGA4
P13612
EBI-702932, EBI-703044
6
FLNA
P21333
EBI-702932, EBI-350432
6