Sequence Browser (P35813-2)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
382

Isoforms (From UniProt)

Isoform
Remark
Ref
P35813-3
No experimental confirmation available. Ref.3 (AK097843) sequence is in conflict in position: 54:Q->R.
VSP_045687
P35813-1
P35813-2  
VSP_005085 VSP_005086
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Protein Information (From UniProt)

Protein:
Protein phosphatase 1A
Other Names:
Protein phosphatase 2C isoform alpha, Protein phosphatase IA
Primary Accession:
P35813
Other Accessions:
B5BU11, J3KNM0, O75551
Gene :
PPM1A*, synonyms (PPPM1A)
Organism :
Human
Entry Name :
PPM1A_HUMAN
Length :
382
Mass (Da) :
42,448
Last modified :
01-Jan-1994
Version :
v1
Isoforms :
3 
Structures :
Experimental 0 | Phyre prediction 1
Function : Show Hide

Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.