Sequence Browser (P48058-2)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
902

Isoforms (From UniProt)

Isoform
Remark
Ref
P48058-2  
No experimental confirmation available.
VSP_042742 VSP_042743
P48058-1
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Protein Information (From UniProt)

Protein:
Glutamate receptor 4
Other Names:
AMPA-selective glutamate receptor 4, GluR-D, Glutamate receptor ionotropic, AMPA 4
Primary Accession:
P48058
Other Accessions:
Q86XE8
Gene :
GRIA4*, synonyms (GLUR4)
Organism :
Human
Entry Name :
GRIA4_HUMAN
Length :
902
Mass (Da) :
100,871
Last modified :
16-Jan-2008
Version :
v2
Isoforms :
2 
Structures :
Experimental 0 | Phyre prediction 2
Function : Show Hide

Receptor for glutamate that functions as ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.