Sequence Browser (P78536-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
824

Isoforms (From UniProt)

Isoform
Remark
Ref
P78536-1  
P78536-2
No experimental confirmation available.
VSP_005478
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Variants (From UniProt)

Type
Variation
Position
sequence variant
K → E
162
sequence conflict
V → A
109
sequence conflict
T → A
801
splice variant
Missing
695 - 824
sequence variant
R → G
202
sequence conflict
D → N
563
sequence conflict
D → N
818

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Protein Information (From UniProt)

Protein:
Disintegrin and metalloproteinase domain-containing protein 17
Other Names:
Snake venom-like protease, TNF-alpha convertase, TNF-alpha-converting enzyme
Primary Accession:
P78536
Other Accessions:
O60226
Gene :
ADAM17*, synonyms (CSVP, TACE)
Organism :
Human
Entry Name :
ADA17_HUMAN
Length :
824
Mass (Da) :
93,021
Last modified :
01-Jan-1997
Version :
v1
Isoforms :
2 
Variants :
7 
Interactions :
3 
Structures :
Experimental 23 | Phyre prediction 4
Function : Show Hide

Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.

Interactions (From UniProt)

With
Entry
IntAct
Exp
MAD2L1
Q13257
EBI-78188, EBI-78203
3
DLG1
Q12959
EBI-78188, EBI-357481
7
Rhbdf2
Q80WQ6
EBI-78188, EBI-647271
2