Sequence Browser (P84022-3)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
425

Isoforms (From UniProt)

Isoform
Remark
Ref
P84022-3  
VSP_043793
P84022-2
No experimental confirmation available.
VSP_042900
P84022-4
No experimental confirmation available.
VSP_045348
P84022-1
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Protein Information (From UniProt)

Protein:
Mothers against decapentaplegic homolog 3
Other Names:
JV15-2, SMAD family member 3
Primary Accession:
P84022
Other Accessions:
A8K4B6, B7Z4Z5, B7Z6M9, B7Z9Q2, F5H383, O09064, O09144, O14510, O35273, Q92940, Q93002, Q9GKR4
Gene :
SMAD3*, synonyms (MADH3)
Organism :
Human
Entry Name :
SMAD3_HUMAN
Length :
425
Mass (Da) :
48,081
Last modified :
05-Jan-2004
Version :
v1
Isoforms :
4 
Structures :
Experimental 0 | Phyre prediction 4
Function : Show Hide

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP-1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and migration of primary keratinocytes and by altering the TGF-mediated chemotaxis of monocytes. This effect on wound healing appears to be hormone-sensitive. Regulator of chondrogenesis and osteogenesis and inhibits early healing of bone fractures. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.