Sequence Browser (Q12986-3)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
1120

Isoforms (From UniProt)

Isoform
Remark
Ref
Q12986-1
Q12986-3  
VSP_033682 VSP_033683
Q12986-2
VSP_033684 VSP_033685
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3D Structure Viewer - JSMol  

3D Structure Display

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Protein Information (From UniProt)

Protein:
Transcriptional repressor NF-X1
Other Names:
Nuclear transcription factor, X box-binding protein 1
Primary Accession:
Q12986
Other Accessions:
A8K6H8, Q5VXW6, Q96EL5, Q9BXI1
Gene :
NFX1*, synonyms (NFX2)
Organism :
Human
Entry Name :
NFX1_HUMAN
Length :
1,120
Mass (Da) :
124,395
Last modified :
20-Jan-2008
Version :
v2
Isoforms :
3 
Structures :
Experimental 0 | Phyre prediction 0
Function : Show Hide

Binds to the X-box motif of MHC class II genes and represses their expression. May play an important role in regulating the duration of an inflammatory response by limiting the period in which MHC class II molecules are induced by interferon-gamma. Isoform 3 binds to the X-box motif of TERT promoter and represses its expression. Together with PABPC1 or PABPC4, isoform 1 acts as a coactivator for TERT expression. Mediates E2-dependent ubiquitination.