Sequence Browser (Q16570-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
336

Isoforms (From UniProt)

Isoform
Remark
Ref
Q16570-1  
Q16570-2
VSP_001323
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Variants (From UniProt)

Type
Variation
Position
splice variant
MGNCLHR → MASSGYVLQ
1 - 7
sequence variant
G → D
42
sequence variant
A → T
100
sequence variant
S → F
326
sequence variant
R → C
89
sequence variant
L → Q
203

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Protein Information (From UniProt)

Protein:
Atypical chemokine receptor 1
Other Names:
Duffy antigen/chemokine receptor, Fy glycoprotein, Glycoprotein D, Plasmodium vivax receptor
Primary Accession:
Q16570
Other Accessions:
A8YPG5, O75898, Q16300, Q8WWE3, Q9UJP0, Q9UKZ5, Q9UKZ6, Q9UQE1
Gene :
ACKR1*, synonyms (DARC, FY, GPD)
Organism :
Human
Entry Name :
ACKR1_HUMAN
Length :
336
Mass (Da) :
35,553
Last modified :
07-Jan-2005
Version :
v3
Isoforms :
2 
Variants :
6 
Interactions :
1 
Structures :
Experimental 2 | Phyre prediction 2
Function : Show Hide

Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.

Interactions (From UniProt)

With
Entry
IntAct
Exp
PVDR
P22290
EBI-15935975, EBI-15935953
3