Sequence Browser (Q68DV7-2)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
783

Isoforms (From UniProt)

Isoform
Remark
Ref
Q68DV7-3
No experimental confirmation available.
VSP_037338
Q68DV7-1
Q68DV7-2  
No experimental confirmation available.
VSP_037339
Q68DV7-4
No experimental confirmation available.
VSP_037340
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Protein Information (From UniProt)

Protein:
E3 ubiquitin-protein ligase RNF43
Other Names:
RING finger protein 43, RING-type E3 ubiquitin transferase RNF43
Primary Accession:
Q68DV7
Other Accessions:
A8K4R2, B7Z443, B7Z5D5, B7Z5J5, Q65ZA4, Q6AI04, Q9NXD0
Gene :
RNF43*
Organism :
Human
Entry Name :
RNF43_HUMAN
Length :
783
Mass (Da) :
85,722
Last modified :
11-Jan-2004
Version :
v1
Isoforms :
4 
Structures :
Experimental 0 | Phyre prediction 3
Function : Show Hide

E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.