Sequence Browser (Q86SE9-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
256

Isoforms (From UniProt)

Isoform
Remark
Ref
Q86SE9-1  
Q86SE9-2
No experimental confirmation available.
VSP_023118 VSP_023119
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
Missing
50 - 256
splice variant
FCKTCIVQHFED → SAESYWMSTWMS
38 - 49

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Polycomb group RING finger protein 5
Other Names:
RING finger protein 159
Primary Accession:
Q86SE9
Other Accessions:
B7Z892, D3DR33, Q6PK47, Q86TD0
Gene :
PCGF5*, synonyms (RNF159)
Organism :
Human
Entry Name :
PCGF5_HUMAN
Length :
256
Mass (Da) :
29,714
Last modified :
01-Jan-2003
Version :
v1
Isoforms :
2 
Variants :
2 
Interactions :
8 
Structures :
Experimental 1 | Phyre prediction 5
Function : Show Hide

Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:26151332). Within the PRC1-like complex, regulates RNF2 ubiquitin ligase activity (PubMed:26151332). Plays a redundant role with PCGF3 as part of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females (By similarity).

Interactions (From UniProt)

With
Entry
IntAct
Exp
BCOR
Q6W2J9-4
EBI-2827999, EBI-10208579
3
PHC2
Q8IXK0
EBI-2827999, EBI-713786
3
RING1
Q06587
EBI-2827999, EBI-752313
6
TRAF2
Q12933
EBI-2827999, EBI-355744
3
AUTS2
Q8WXX7
EBI-2827999, EBI-2875359
6
CBX8
Q9HC52
EBI-2827999, EBI-712912
4
PRMT6
Q96LA8
EBI-2827999, EBI-912440
2
RNF2
Q99496
EBI-2827999, EBI-722416
7