Sequence Browser (Q86TL0-2)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
474

Isoforms (From UniProt)

Isoform
Remark
Ref
Q86TL0-1
Q86TL0-2  
No experimental confirmation available.
VSP_056671
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3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Cysteine protease ATG4D
Other Names:
AUT-like 4 cysteine endopeptidase, Autophagin-4, Autophagy-related cysteine endopeptidase 4, Autophagy-related protein 4 homolog D
Primary Accession:
Q86TL0
Other Accessions:
Q969K0
Gene :
ATG4D*, synonyms (APG4D, AUTL4)
Organism :
Human
Entry Name :
ATG4D_HUMAN
Length :
474
Mass (Da) :
52,922
Last modified :
01-Jan-2003
Version :
v1
Isoforms :
2 
Structures :
Experimental 0 | Phyre prediction 1
Function : Show Hide

Cysteine protease ATG4D: Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins MAP1LC3 and GABARAPL2, to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Has also an activity of delipidating enzyme for the PE-conjugated forms.

Cysteine protease ATG4D, mitochondrial: Plays a role as an autophagy regulator that links mitochondrial dysfunction with apoptosis. The mitochondrial import of ATG4D during cellular stress and differentiation may play important roles in the regulation of mitochondrial physiology, ROS, mitophagy and cell viability.