Sequence Browser (Q8N1L9-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
274

Isoforms (From UniProt)

Isoform
Remark
Ref
Q8N1L9-2
VSP_025752
Q8N1L9-1  
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Variants (From UniProt)

Type
Variation
Position
sequence variant
G → S
6
splice variant
Missing
1 - 85

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Protein Information (From UniProt)

Protein:
Basic leucine zipper transcriptional factor ATF-like 2
Other Names:
Suppressor of AP-1 regulated by IFN
Primary Accession:
Q8N1L9
Other Accessions:
D9IC56, Q8NAF4, Q8NAL8, Q96EH4
Gene :
BATF2*
Organism :
Human
Entry Name :
BATF2_HUMAN
Length :
274
Mass (Da) :
29,398
Last modified :
01-Jan-2002
Version :
v1
Isoforms :
2 
Variants :
2 
Interactions :
3 
Structures :
Experimental 0 | Phyre prediction 3
Function : Show Hide

AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CYR61/CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CYR61 and inhibits CYR61-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CYR61 promoter.

Interactions (From UniProt)

With
Entry
IntAct
Exp
DAZAP2
Q15038
EBI-742695, EBI-724310
3
JUNB
P17275
EBI-742695, EBI-748062
3
JUN
P05412
EBI-15746052, EBI-852823
3