Sequence Browser (Q92851-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
521

Isoforms (From UniProt)

Isoform
Remark
Ref
Q92851-1  
Q92851-6
Variant in position: 455:L->I (in dbSNP:rs13006529).
VSP_037229 VSP_000820
Q92851-2
May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Variant in position: 479:L->I (in dbSNP:rs13006529).
VSP_000819 VSP_000820
Q92851-3
May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
VSP_000821 VSP_000822
Q92851-5
VSP_000819
Q92851-4
Variant in position: 522:L->I (not associated with significantly altered cutaneous melanoma risk, dbSNP:rs13006529).
VSP_000820
Q92851-7
VSP_053333 VSP_053334
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
Missing
229 - 271
splice variant
Missing
241 - 307
splice variant
Missing
248 - 521
splice variant
MLKFLEKTMEIRGRKRTVWGAKQISATSLPTAISAQTPRPPMRRWSSVS → HEDILSILTAVNDDVSRRVDKQGTKKQMPQPAFTLRKKLVFPVPLDALSL
473 - 521
sequence variant
R → C
21
sequence variant
S → C
239
sequence variant
L → P
285
sequence variant
V → I
410
sequence variant
P → S
444
mutagenesis site
C → A
401
sequence conflict
T → A
268
splice variant
QESWQNKHAGSNGNRATNG → EGVFVFLNEGDRGNSPDDL
229 - 247
splice variant
GNRATNGAPSLVSRGMQGASANTLNSETSTKRA → EGSCVQDESEPQRPLCHCQQPQLYLPEGQTRNP
241 - 273
splice variant
Missing
274 - 521
sequence variant
K → T
14
sequence variant
M → T
147
sequence variant
L → F
285
sequence variant
I → L
406
sequence variant
A → V
414
sequence variant
Y → C
446
sequence conflict
E → G
68

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Caspase-10
Other Names:
Apoptotic protease Mch-4, FAS-associated death domain protein interleukin-1B-converting enzyme 2, ICE-like apoptotic protease 4
Primary Accession:
Q92851
Other Accessions:
Q68HC0, Q6KF62, Q6KF63, Q8IUP5, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7
Gene :
CASP10*, synonyms (MCH4)
Organism :
Human
Entry Name :
CASPA_HUMAN
Length :
521
Mass (Da) :
58,951
Last modified :
11-Jan-2001
Version :
v3
Isoforms :
7 
Variants :
21 
Interactions :
5 
Structures :
Experimental 0 | Phyre prediction 5
Function : Show Hide

Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC.

Isoform 7 can enhance NF-kappaB activity but promotes only slight apoptosis.

Isoform C is proteolytically inactive.

Interactions (From UniProt)

With
Entry
IntAct
Exp
CASP8
Q14790
EBI-495095, EBI-78060
3
RIOK3
O14730
EBI-495095, EBI-1047061
6
XIAP
P98170
EBI-495095, EBI-517127
3
CFLAR
O15519
EBI-495095, EBI-514941
3
RIPK1
Q13546
EBI-495095, EBI-358507
2