Sequence Browser (Q96KB5-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
322

Isoforms (From UniProt)

Isoform
Remark
Ref
Q96KB5-2
No experimental confirmation available.
VSP_055269
Q96KB5-1  
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
sequence variant
N → S
107
sequence variant
M → L
241
mutagenesis site
KK → AA
64 - 65
mutagenesis site
V → A
322
sequence conflict
K → E
169
splice variant
T → TAPAFITILLVS
198
sequence variant
E → D
220
mutagenesis site
T → E
9
mutagenesis site
T → A
320
sequence conflict
F → I
34
sequence conflict
D → N
254

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Lymphokine-activated killer T-cell-originated protein kinase
Other Names:
Cancer/testis antigen 84, MAPKK-like protein kinase, Nori-3, PDZ-binding kinase, Spermatogenesis-related protein kinase, T-LAK cell-originated protein kinase
Primary Accession:
Q96KB5
Other Accessions:
B4DX68, D3DST2, Q9NPD9, Q9NYL7, Q9NZK6
Gene :
PBK*, synonyms (TOPK)
Organism :
Human
Entry Name :
TOPK_HUMAN
Length :
322
Mass (Da) :
36,085
Last modified :
06-Jan-2005
Version :
v3
Isoforms :
2 
Variants :
11 
Interactions :
2 
Structures :
Experimental 2 | Phyre prediction 2
Function : Show Hide

Phosphorylates MAP kinase p38. Seems to be active only in mitosis. May also play a role in the activation of lymphoid cells. When phosphorylated, forms a complex with TP53, leading to TP53 destabilization and attenuation of G2/M checkpoint during doxorubicin-induced DNA damage.

Interactions (From UniProt)

With
Entry
IntAct
Exp
ARAF
P10398
EBI-536853, EBI-365961
3
TP53
P04637
EBI-536853, EBI-366083
7