Sequence Browser (Q9GZX7-2)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
198

Isoforms (From UniProt)

Isoform
Remark
Ref
Q9GZX7-1
Q9GZX7-2  
VSP_047803
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Protein Information (From UniProt)

Protein:
Single-stranded DNA cytosine deaminase
Other Names:
Activation-induced cytidine deaminase, Cytidine aminohydrolase
Primary Accession:
Q9GZX7
Other Accessions:
Q6QJ81, Q8NFC1
Gene :
AICDA*, synonyms (AID)
Organism :
Human
Entry Name :
AICDA_HUMAN
Length :
198
Mass (Da) :
23,954
Last modified :
01-Jan-2001
Version :
v1
Isoforms :
2 
Structures :
Experimental 0 | Phyre prediction 2
Function : Show Hide

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses (PubMed:18722174, PubMed:21385873, PubMed:21518874, PubMed:27716525). May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation (PubMed:21496894).