Sequence Browser (Q9NSU2-1)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
314
Isoform
Remark
Ref
VSP_010445
Q9NSU2-1  
VSP_059279
Click on Isoform of interest to be redirected to the corresponding page
Type
Variation
Position
splice variant
Missing
1 - 10
splice variant
M → MGPGARRQGRIVQGRPEMCFCPPPTPLPPLRILTLGTHTPTPCSSPGSAAGTYPTM
1
sequence variant
D → N
18
sequence variant
R → H
114
sequence variant
V → A
122
sequence variant
A → V
158
sequence variant
E → K
198
sequence variant
D → DD
200
sequence variant
D → H
200
sequence variant
D → N
200
sequence variant
V → D
201
sequence variant
G → S
227
sequence variant
R → S
240
sequence variant
A → P
247
sequence variant
E → G
266
sequence variant
P → L
290
sequence variant
T → P
303
sequence variant
Y → C
305
sequence variant
G → A
306
mutagenesis site
K → R
30
mutagenesis site
K → R
66
mutagenesis site
K → R
75
mutagenesis site
K → R
160
mutagenesis site
K → R
175
mutagenesis site
K → R
242
mutagenesis site
K → R
271
mutagenesis site
K → R
277
sequence conflict
G → R
265

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Protein:
Other Names:
3'-5' exonuclease TREX1, Deoxyribonuclease III
Primary Accession:
Other Accessions:
B2RCN9, Q8TEU2, Q9BPW1, Q9Y4X2
Gene :
TREX1*
Organism :
Human
Entry Name :
Length :
314
Mass (Da) :
33,212
Last modified :
20-Jan-2017
Version :
v2
Isoforms :
3 
Variants :
28 
Interactions :
2 
Structures :
Experimental 0 | Phyre prediction 1

Major cellular 3'-to-5' DNA exonuclease which digests single-stranded DNA (ssDNA) and double-stranded DNA (dsDNA) with mismatched 3' termini. Prevents cell-intrinsic initiation of autoimmunity. Acts by metabolizing DNA fragments from endogenous retroelements, including L1, LTR and SINE elements. Unless degraded, these DNA fragments accumulate in the cytosol and activate the IFN-stimulatory DNA (ISD) response and innate immune signaling. Prevents chronic ATM-dependent checkpoint activation, by processing ssDNA polynucleotide species arising from the processing of aberrant DNA replication intermediates. Inefficiently degrades oxidized DNA, such as that generated upon antimicrobial reactive oxygen production or upon absorption of UV light. During GZMA-mediated cell death, contributes to DNA damage in concert with NME1. NME1 nicks one strand of DNA and TREX1 removes bases from the free 3' end to enhance DNA damage and prevent DNA end reannealing and rapid repair.

With
Entry
IntAct
Exp
KRTAP10-7
P60409-2
EBI-16746122, EBI-10695388
3
KRTAP10-7
P60409
EBI-16746122, EBI-10172290
3