Sequence Browser (Q9NZC7-5)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
414

Isoforms (From UniProt)

Isoform
Remark
Ref
Q9NZC7-4
VSP_016358 VSP_016359
Q9NZC7-5  
VSP_016363
Q9NZC7-7
VSP_016362 VSP_016366
Q9NZC7-1
Q9NZC7-2
VSP_016367 VSP_016369
Q9NZC7-3
Variant in position: 182:K->E (found in a primary colorectal tumor and tumor cells).
VSP_016364 VSP_016365
Q9NZC7-6
VSP_016360
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3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
WW domain-containing oxidoreductase
Other Names:
Fragile site FRA16D oxidoreductase, Short chain dehydrogenase/reductase family 41C member 1
Primary Accession:
Q9NZC7
Other Accessions:
A8K323, Q5MYT5, Q96KM3, Q96RF2, Q9BTT8, Q9NPC9, Q9NRF4, Q9NRF5, Q9NRF6, Q9NRK1, Q9NZC5
Gene :
WWOX*, synonyms (FOR, SDR41C1, WOX1)
Organism :
Human
Entry Name :
WWOX_HUMAN
Length :
414
Mass (Da) :
46,677
Last modified :
01-Jan-2000
Version :
v1
Isoforms :
7 
Structures :
Experimental 0 | Phyre prediction 5
Function : Show Hide

Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm.