Sequence Browser (Q9UK53-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
422

Isoforms (From UniProt)

Isoform
Remark
Ref
Q9UK53-5
VSP_009128
Q9UK53-3
VSP_009129
Q9UK53-1  
Q9UK53-2
VSP_009126
Q9UK53-4
VSP_009127
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
MSFVECPYHSPAERLVAEADEGGPSAITGMGLCFRCLLFSFSGRSGVEGGRVDLNVFGSLGLQPWIGSSRCWGGPCSSALRCGWFSSWPPPSKSAIPIGGGSRGAGRVSRWPPPHWLEAWRVSPLPLSPLSPATFGRGFIAVAVIPGLWARGRGCSSDRLPRPAGPARRQFQAASLLTRGWGRAWPWKQ → MLSPANGEQLHLVNYVEDYLDSIESLPFDLQRNVSLMREIDAKYQE
1 - 189
splice variant
MSFVECPYHSPAERLVAEADEGGPSAITGMGLCFRCLLFSFSGRSGVEGGRVDLNVFGSLGLQPWIGSSRCWGGPCSSALRCGWFSSWPPPSKSAIPIGGGSRGAGRVSRWPPPHWLEAWRVSPLPLSPLSPATFGRGFIAVAVIPGLWARGRGCSSDRLPRPAGPARRQFQAASLLTRGWGRAWPWKQ → MSFVECPYHSPAERLVAEADEGGPSAITE
1 - 189
sequence variant
A → D
335
sequence variant
N → S
359
sequence conflict
A → V
266
sequence conflict
K → N
278
sequence conflict
A → V
282
splice variant
Missing
1 - 212
splice variant
MSFVECPYHSPAERLVAEADEGGPSAITGMGLCFRCLLFSFSGRSGVEGGRVDLNVFGSLGLQPWIGSSRCWGGPCSSALRCGWFSSWPPPSKSAIPIGGGSRGAGRVSRWPPPHWLEAWRVSPLPLSPLSPATFGRGFIAVAVIPGLWARGRGCSSDRLPRPAGPARRQFQAASLLTRGWGRAWPWKQ → ME
1 - 189
sequence variant
L → R
125
sequence variant
C → S
358
mutagenesis site
W → A
378
sequence conflict
A → V
272
sequence conflict
E → D
280
sequence conflict
A → S
285

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Inhibitor of growth protein 1
Primary Accession:
Q9UK53
Other Accessions:
O00532, O43658, Q53ZR3, Q5T9G8, Q5T9G9, Q5T9H0, Q5T9H1, Q9H007, Q9HD98, Q9HD99, Q9NS83, Q9P0U6, Q9UBC6, Q9UIJ1, Q9UIJ2, Q9UIJ3, Q9UIJ4, Q9UK52
Gene :
ING1*
Organism :
Human
Entry Name :
ING1_HUMAN
Length :
422
Mass (Da) :
46,738
Last modified :
04-Jan-2008
Version :
v2
Isoforms :
5 
Variants :
15 
Interactions :
1 
Structures :
Experimental 1 | Phyre prediction 4
Function : Show Hide

Cooperates with p53/TP53 in the negative regulatory pathway of cell growth by modulating p53-dependent transcriptional activation. Implicated as a tumor suppressor gene.

Interactions (From UniProt)

With
Entry
IntAct
Exp
NQO1
P15559
EBI-399198, EBI-3989435
3