Sequence Browser (Q9Y252-2)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
685

Isoforms (From UniProt)

Isoform
Remark
Ref
Q9Y252-2  
No experimental confirmation available.
VSP_055424 VSP_055425
Q9Y252-3
VSP_055426 VSP_055427
Q9Y252-1
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3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
E3 ubiquitin-protein ligase RNF6
Other Names:
RING-type E3 ubiquitin transferase RNF6
Primary Accession:
Q9Y252
Other Accessions:
B4DDP0, Q5W0H0, Q9BZP5, Q9UF41
Gene :
RNF6*, synonyms (SPG2)
Organism :
Human
Entry Name :
RNF6_HUMAN
Length :
685
Mass (Da) :
78,091
Last modified :
01-Jan-1999
Version :
v1
Isoforms :
3 
Structures :
Experimental 0 | Phyre prediction 2
Function : Show Hide

E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator.