Sequence Browser (Q9Y275-3)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
285

Isoforms (From UniProt)

Isoform
Remark
Ref
Q9Y275-1
Q9Y275-2
VSP_041183
Q9Y275-3  
VSP_047591 VSP_047592
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Protein Information (From UniProt)

Protein:
Tumor necrosis factor ligand superfamily member 13B
Other Names:
B lymphocyte stimulator, B-cell-activating factor, BAFF, Dendritic cell-derived TNF-like molecule, TNF- and APOL-related leukocyte expressed ligand 1
Primary Accession:
Q9Y275
Other Accessions:
E0ADT7, Q6FHD6, Q7Z5J2
Gene :
TNFSF13B*, synonyms (BAFF, BLYS, TALL1, TNFSF20, ZTNF4)
Organism :
Human
Entry Name :
TN13B_HUMAN
Length :
285
Mass (Da) :
31,223
Last modified :
01-Jan-1999
Version :
v1
Isoforms :
3 
Structures :
Experimental 0 | Phyre prediction 0
Function : Show Hide

Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.

Isoform 2 seems to inhibit isoform 1 secretion and bioactivity.

Isoform 3: Acts as a transcription factor for its own parent gene, in association with NF-kappa-B p50 subunit, at least in autoimmune and proliferative B-cell diseases. The presence of Delta4BAFF is essential for soluble BAFF release by IFNG/IFN-gamma-stimulated monocytes and for B-cell survival. It can directly or indirectly regulate the differential expression of a large number of genes involved in the innate immune response and the regulation of apoptosis.