Sequence Browser (P60484-1)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
403
Isoform
Remark
Ref
VSP_055421 VSP_055422 VSP_055423
P60484-1  
Produced by alternative initiation at a CTG start codon of isoform 1. May contain a signal peptide at positions 1-21.
VSP_055420
Click on Isoform of interest to be redirected to the corresponding page
Type
Variation
Position
splice variant
GVTIPSQRRYVYYYSYLLKNHLDYRP → ADPTGGIPDKGIIVIGDGSSMDVIAP
165 - 190
sequence variant
S → N
10
sequence variant
Y → C
16
sequence variant
G → E
20
sequence variant
Missing
33
sequence variant
M → R
35
sequence variant
G → R
36
sequence variant
R → G
47
sequence variant
H → D
61
sequence variant
Missing
65 - 403
sequence variant
Y → H
68
sequence variant
C → Y
71
sequence variant
H → Y
93
sequence variant
C → Y
105
sequence variant
L → P
112
sequence variant
V → L
119
sequence variant
A → P
121
sequence variant
H → Y
123
sequence variant
C → S
124
sequence variant
G → E
129
sequence variant
R → G
130
sequence variant
R → Q
130
sequence variant
G → V
132
sequence variant
M → L
134
sequence variant
C → Y
136
sequence variant
Y → C
155
sequence variant
G → E
165
sequence variant
G → V
165
sequence variant
T → P
167
sequence variant
S → R
170
sequence variant
R → H
173
sequence variant
Y → N
174
sequence variant
V → I
217
sequence variant
R → Q
234
sequence variant
P → L
246
splice variant
M → MERGGEAAAAAAAAAAAPGRGSESPVTISRAGNAGELVSPLLLPPTRRRRRRHIQGPGPVLNLPSAAAAPPVARAPEAAGGGSRSEDYSSSPHSAAAAARPLAAEEKQAQSLQPSSSRRSSHYPAAVQSQAAAERGASATAKSRAISILQKKPRHQQLLPSLSSFFFSHRLPDM
1
splice variant
RFLDSKHKNHYKIYNL → S
55 - 70
splice variant
Missing
191 - 403
sequence variant
R → S
15
sequence variant
D → N
19
sequence variant
Y → S
27
sequence variant
A → D
34
sequence variant
G → E
36
sequence variant
L → R
42
sequence variant
L → W
57
sequence variant
H → R
61
sequence variant
I → R
67
sequence variant
L → P
70
sequence variant
H → R
93
sequence variant
C → F
105
sequence variant
D → Y
107
sequence variant
L → R
112
sequence variant
A → G
121
sequence variant
H → R
123
sequence variant
C → R
124
sequence variant
A → G
126
sequence variant
G → R
129
sequence variant
R → L
130
sequence variant
T → I
131
sequence variant
V → I
133
sequence variant
I → V
135
sequence variant
A → AN
137
sequence variant
V → L
158
sequence variant
G → R
165
sequence variant
T → N
167
sequence variant
S → N
170
sequence variant
R → C
173
sequence variant
R → P
173
sequence variant
V → A
191
sequence variant
S → F
227
sequence variant
F → S
241
sequence variant
G → C
251
sequence variant
K → E
289
sequence variant
D → G
252
sequence variant
V → L
290
sequence variant
D → G
331
sequence variant
K → N
342
sequence variant
L → Q
345
sequence variant
T → I
348
sequence variant
T → I
401
mutagenesis site
K → E
13
mutagenesis site
H → A
93
mutagenesis site
K → M
125
mutagenesis site
A → S
126
mutagenesis site
K → M
128
mutagenesis site
R → M
130
mutagenesis site
Q → A,E
171
mutagenesis site
K → E
289
mutagenesis site
Y → F
336
mutagenesis site
S → A
370
mutagenesis site
K → A
402
mutagenesis site
V → A
403
sequence variant
Missing
319
sequence variant
F → V
341
sequence variant
V → E
343
sequence variant
F → L
347
sequence variant
V → G
369
mutagenesis site
M → I
1
mutagenesis site
D → A
92
mutagenesis site
C → A
124
mutagenesis site
A → P
126
mutagenesis site
A → V
126
mutagenesis site
K → R
128
mutagenesis site
T → A,D
167
mutagenesis site
KMLKKDK → AAGAADA
263 - 269
mutagenesis site
KANKDKANR → AAGADAANA
327 - 335
mutagenesis site
T → A
366
mutagenesis site
T → A
401
mutagenesis site
K → W
402

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Protein:
Other Names:
Mutated in multiple advanced cancers 1, Phosphatase and tensin homolog
Primary Accession:
Other Accessions:
B2R904, F2YHV0, O00633, O02679, Q6ICT7
Gene :
PTEN*, synonyms (MMAC1, TEP1)
Organism :
Human
Entry Name :
Length :
403
Mass (Da) :
47,166
Last modified :
16-Jan-2004
Version :
v1
Isoforms :
3 
Variants :
109 
Interactions :
23 
Structures :
Experimental 6 | Phyre prediction 2

Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4 (PubMed:26504226). The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability. In motile cells, suppresses the formation of lateral pseudopods and thereby promotes cell polarization and directed movement.

Isoform alpha: Functional kinase, like isoform 1 it antagonizes the PI3K-AKT/PKB signaling pathway. Plays a role in mitochondrial energetic metabolism by promoting COX activity and ATP production, via collaboration with isoform 1 in increasing protein levels of PINK1.

With
Entry
IntAct
Exp
Itself
EBI-696162, EBI-696162
9
CDC27
P30260
EBI-696162, EBI-994813
7
Dlg1
Q62696
EBI-696162, EBI-389325
2
FRK
P42685
EBI-696162, EBI-1383583
7
Magi3
Q9JK71
EBI-696162, EBI-696226
3
Mast2
Q60592
EBI-696162, EBI-493888
4
NCOA3
Q9Y6Q9
EBI-696162, EBI-81196
2
OTUD3
Q5T2D3
EBI-15722967, EBI-16170539
9
PPP1CA
P62136
EBI-696162, EBI-357253
2
SLC9A3R1
O14745
EBI-696162, EBI-349787
7
Slc9a3r2
Q9JHL1
EBI-696162, EBI-538451
2
USP7
Q93009
EBI-15722967, EBI-302474
5
BMI1
P35226
EBI-696162, EBI-2341576
7
DBN1
Q16643
EBI-696162, EBI-351394
5
ECSCR
Q19T08
EBI-15722967, EBI-15778214
4
Magi2
O88382
EBI-696162, EBI-696179
3
Mast1
Q9R1L5
EBI-696162, EBI-491771
3
MAST3
O60307
EBI-696162, EBI-311420
3
NEDD4
P46934
EBI-696162, EBI-726944
4
PDGFRB
P09619
EBI-696162, EBI-641237
3
PRDX1
Q06830
EBI-696162, EBI-353193
7
SLC9A3R2
Q15599
EBI-696162, EBI-1149760
5
SPOP
O43791
EBI-696162, EBI-743549
4