Sequence Browser (Q7Z6B7-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
1085

Isoforms (From UniProt)

Isoform
Remark
Ref
Q7Z6B7-1  
Q7Z6B7-2
No experimental confirmation available.
VSP_010580
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Variants (From UniProt)

Type
Variation
Position
sequence variant
Q → H
149
sequence variant
V → I
512
sequence variant
H → R
875
splice variant
RPPNVPPKPQKHRKSRPRSQYNTKLFNGDLETFVK → SRGRRNSHTRHQ
479 - 513
sequence variant
A → T
275
sequence variant
R → C
617

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
SLIT-ROBO Rho GTPase-activating protein 1
Other Names:
Rho GTPase-activating protein 13
Primary Accession:
Q7Z6B7
Other Accessions:
Q9H8A3, Q9P2P2
Gene :
SRGAP1*, synonyms (ARHGAP13, KIAA1304)
Organism :
Human
Entry Name :
SRGP1_HUMAN
Length :
1,085
Mass (Da) :
124,264
Last modified :
01-Jan-2003
Version :
v1
Isoforms :
2 
Variants :
6 
Interactions :
2 
Structures :
Experimental 0 | Phyre prediction 5
Function : Show Hide

GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.

Interactions (From UniProt)

With
Entry
IntAct
Exp
HTT
P42858
EBI-2481729, EBI-466029
4
ARHGEF7
Q14155
EBI-2481729, EBI-717515
4