Sequence Browser (Q96C92-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
If the whole structure is coloured grey in '3D Structure Viewer' panel, please click the icon - on the top left corner of the viewer.
(If nothing changes then 'Sequence ↔ Structure' mapping may be unavailable).
1
435

Isoforms (From UniProt)

Isoform
Remark
Ref
Q96C92-2
VSP_032177
Q96C92-1  
Q96C92-4
No experimental confirmation available.
VSP_040477
Q96C92-3
VSP_032176
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
Missing
24 - 96
sequence variant
L → V
157
sequence variant
R → Q
304
sequence variant
V → I
428
mutagenesis site
E → A
194
sequence conflict
N → T
343
splice variant
Missing
1 - 58
splice variant
Missing
75 - 97
sequence variant
E → G
176
sequence variant
V → M
379
mutagenesis site
P → A
190
sequence conflict
R → H
7

3D Structure Viewer - JSMol  

To analyse the structural impact of your missense variant:

  • Select the corresponding experimental/modelled structure from the "Available Structures" Panel.
  • Right-click on the target structure and download it.
  • Go to our web server Missense3D to analyse structural impact.

    • Go to Missense3D

Protein Information (From UniProt)

Protein:
Serologically defined colon cancer antigen 3
Other Names:
Antigen NY-CO-3
Primary Accession:
Q96C92
Other Accessions:
A6NCP1, O60525, Q5SXN1, Q5SXN2, Q5SXN3, Q5SXN4, Q5SXN8, Q6V704, Q9NVY5
Gene :
SDCCAG3*
Organism :
Human
Entry Name :
SDCG3_HUMAN
Length :
435
Mass (Da) :
47,961
Last modified :
18-Jan-2008
Version :
v3
Isoforms :
4 
Variants :
12 
Interactions :
5 
Structures :
Experimental 0 | Phyre prediction 1
Function : Show Hide

May be involved in modulation of TNF response. May be involved in presentation of TNFRSF1A on the cell surface (By similarity). Involved in the endosome-to-plasma membrane trafficking and recycling of SNX27-retromer-dependent cargo proteins, such as GLUT1 (PubMed:25278552). Involved in the regulation of cytokinesis; the function may involve PTPN13 and GIT1 (PubMed:23108400).

Interactions (From UniProt)

With
Entry
IntAct
Exp
AXIN1
A0A0S2Z4M1
EBI-10178036, EBI-16429430
3
AP1M1
Q9BXS5
EBI-10178036, EBI-541426
3
DDX6
P26196
EBI-10178036, EBI-351257
3
TFPT
P0C1Z6-2
EBI-10178036, EBI-10178002
3
SDCBP
O00560
EBI-10178036, EBI-727004
3