Sequence Browser (Q05823-1)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
741
Isoform
Remark
Ref
VSP_056272 VSP_056273
Q05823-1  
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Type
Variation
Position
splice variant
INECVMKKMNKFYEKRG → MSKLRHRQIIFPTTQNQ
636 - 652
splice variant
Missing
653 - 741
sequence variant
G → S
59
sequence variant
I → L
97
sequence variant
A → T
289
sequence variant
S → F
406
sequence variant
R → Q
462
sequence variant
D → E
541
sequence variant
R → H
592
mutagenesis site
K → N
240
mutagenesis site
K → N
274
mutagenesis site
K → R
392
mutagenesis site
H → A
583
mutagenesis site
P → A
584
mutagenesis site
W → A
632
mutagenesis site
D → A
661
mutagenesis site
R → A
667
mutagenesis site
H → A
672

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Protein:
Other Names:
Ribonuclease 4, Ribonuclease L
Primary Accession:
Other Accessions:
Q5W0L2, Q6AI46
Gene :
RNASEL*, synonyms (RNS4)
Organism :
Human
Entry Name :
Length :
741
Mass (Da) :
83,533
Last modified :
Jan 1, 1996
Version :
v2
Isoforms :
2 
Variants :
18 
Interactions :
1 
Structures :
Experimental 5 | Phyre prediction 3

Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979). Might play a central role in the regulation of mRNA turnover (PubMed:11585831). Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length.

With
Entry
IntAct
Exp
IQGAP1
P46940
EBI-8390477, EBI-297509
2