Sequence Browser (P45379-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
If the whole structure is coloured grey in '3D Structure Viewer' panel, please click the icon - on the top left corner of the viewer.
(If nothing changes then 'Sequence ↔ Structure' mapping may be unavailable).
1
298

Isoforms (From UniProt)

Isoform
Remark
Ref
P45379-6
VSP_006643
P45379-12
VSP_006645 VSP_006646 VSP_006648
P45379-10
VSP_006648
P45379-1  
P45379-2
VSP_006644
P45379-4
VSP_006644 VSP_006645
P45379-5
VSP_006647
P45379-8
VSP_006641
P45379-9
VSP_006646
P45379-11
No experimental confirmation available.
VSP_006643 VSP_006648
P45379-3
VSP_006645
P45379-7
VSP_006642
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
Missing
18 - 32
splice variant
Missing
23 - 32
splice variant
Missing
18 - 22
splice variant
Missing
23
splice variant
Missing
99 - 137
splice variant
Missing
201
sequence variant
F → L
80
sequence variant
R → L
102
sequence variant
R → W
102
sequence variant
A → V
114
sequence variant
F → V
120
sequence variant
R → C
140
sequence variant
R → W
141
sequence variant
Missing
170
sequence variant
S → F
189
sequence variant
R → L
215
sequence variant
I → T
221
sequence variant
S → T
249
sequence variant
K → R
263
sequence variant
N → I
281
sequence variant
R → P
288
sequence conflict
K → E
242
splice variant
Missing
54
splice variant
Missing
201 - 203
sequence variant
A → V
38
sequence variant
I → N
89
sequence variant
R → Q
102
sequence variant
R → L
104
sequence variant
F → I
120
sequence variant
R → K
139
sequence variant
R → K
140
sequence variant
R → W
151
sequence variant
E → K
173
sequence variant
Missing
210
sequence variant
Missing
220
sequence variant
I → T
231
sequence variant
E → D
254
sequence variant
N → Y
279
sequence variant
R → C
288
sequence variant
R → C
296

3D Structure Viewer - JSMol  

To analyse the structural impact of your missense variant:

  • Select the corresponding experimental/modelled structure from the "Available Structures" Panel.
  • Right-click on the target structure and download it.
  • Go to our web server Missense3D to analyse structural impact.

    • Go to Missense3D

Protein Information (From UniProt)

Protein:
Troponin T, cardiac muscle
Other Names:
Cardiac muscle troponin T
Primary Accession:
P45379
Other Accessions:
A2TDB9, A8K3K6, O60214, Q99596, Q99597, Q9BUF6, Q9UM96
Gene :
TNNT2*
Organism :
Human
Entry Name :
TNNT2_HUMAN
Length :
298
Mass (Da) :
35,924
Last modified :
23-Jan-2007
Version :
v3
Isoforms :
12 
Variants :
40 
Interactions :
1 
Structures :
Experimental 3 | Phyre prediction 3
Function : Show Hide

Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.

Interactions (From UniProt)

With
Entry
IntAct
Exp
MORF4L2
Q15014
EBI-8485957, EBI-399257
3