Sequence Browser (P15056-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
766

Isoforms (From UniProt)

Isoform
Remark
Ref
P15056-1  
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
sequence variant
T → P
241
sequence variant
T → P
244
sequence variant
A → P
246
sequence variant
Q → K
262
sequence variant
R → I
462
sequence variant
G → E
464
sequence variant
G → A
466
sequence variant
G → V
466
sequence variant
F → S
468
sequence variant
G → E
469
sequence variant
G → V
469
sequence variant
K → E
499
sequence variant
E → G
501
sequence variant
L → P
525
sequence variant
N → D
580
sequence variant
N → S
581
sequence variant
D → G
594
sequence variant
G → R
596
sequence variant
L → R
597
sequence variant
T → R
599
sequence variant
V → E
600
sequence variant
K → Q
601
sequence variant
Q → R
709
mutagenesis site
K → R
578
sequence conflict
H → D
766
sequence variant
T → M
241
sequence variant
T → R
241
sequence variant
L → F
245
sequence variant
Q → R
257
sequence variant
E → K
275
sequence variant
P → S
301
sequence variant
I → S
463
sequence variant
G → V
464
sequence variant
G → E
466
sequence variant
S → A
467
sequence variant
G → A
469
sequence variant
G → R
469
sequence variant
L → F
485
sequence variant
K → N
499
sequence variant
E → K
501
sequence variant
W → C
531
sequence variant
N → D
581
sequence variant
E → K
586
sequence variant
F → L
595
sequence variant
G → V
596
sequence variant
L → V
597
sequence variant
V → D
600
sequence variant
K → E
601
sequence variant
D → E
638
mutagenesis site
K → S
483
mutagenesis site
R → K
671

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Serine/threonine-protein kinase B-raf
Other Names:
Proto-oncogene B-Raf, p94, v-Raf murine sarcoma viral oncogene homolog B1
Primary Accession:
P15056
Other Accessions:
A4D1T4, B6HY61, B6HY62, B6HY63, B6HY64, B6HY65, B6HY66, Q13878, Q3MIN6, Q9UDP8, Q9Y6T3
Gene :
BRAF*, synonyms (BRAF1, RAFB1)
Organism :
Human
Entry Name :
BRAF_HUMAN
Length :
766
Mass (Da) :
84,437
Last modified :
19-Jan-2004
Version :
v4
Isoforms :
1 
Variants :
51 
Interactions :
18 
Structures :
Experimental 68 | Phyre prediction 5
Function : Show Hide

Protein kinase involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May play a role in the postsynaptic responses of hippocampal neuron. Phosphorylates MAP2K1, and thereby contributes to the MAP kinase signal transduction pathway.

Interactions (From UniProt)

With
Entry
IntAct
Exp
ARAF
P10398
EBI-365980, EBI-365961
3
HSP90AB1
P08238
EBI-365980, EBI-352572
2
Ksr1
Q61097
EBI-365980, EBI-1536336
3
MAP2K1
Q02750
EBI-365980, EBI-492564
58
MAP3K1
Q13233
EBI-365980, EBI-49776
2
RAF1
P04049
EBI-365980, EBI-365996
55
Rgs12
Q8CGE9
EBI-365980, EBI-7340552
2
TRAF3
Q13114
EBI-365980, EBI-357631
2
YWHAZ
P63104
EBI-365980, EBI-347088
4
Itself
EBI-365980, EBI-365980
13
HRAS
P01112
EBI-365980, EBI-350145
4
IQGAP1
P46940
EBI-365980, EBI-297509
4
MAP2K1
P29678
EBI-365980, EBI-1631983
2
MAP2K2
P36507
EBI-365980, EBI-1056930
6
NRAS
P01111
EBI-365980, EBI-721993
3
Raf1
Q99N57
EBI-365980, EBI-397757
3
RPS6KA2
Q15349
EBI-365980, EBI-1384149
2
YWHAB
P31946
EBI-365980, EBI-359815
3