Sequence Browser (O43513-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
233

Isoforms (From UniProt)

Isoform
Remark
Ref
O43513-1  
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Variants (From UniProt)

No variants reported for this protein.

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Protein Information (From UniProt)

Protein:
Mediator of RNA polymerase II transcription subunit 7
Other Names:
Activator-recruited cofactor 34 kDa component, Cofactor required for Sp1 transcriptional activation subunit 9, Mediator complex subunit 7, RNA polymerase transcriptional regulation mediator subunit 7 homolog, Transcriptional coactivator CRSP33
Primary Accession:
O43513
Other Accessions:
Gene :
MED7*, synonyms (ARC34, CRSP9)
Organism :
Human
Entry Name :
MED7_HUMAN
Length :
233
Mass (Da) :
27,245
Last modified :
01-Jan-1998
Version :
v1
Isoforms :
1 
Variants :
0 
Interactions :
6 
Structures :
Experimental 0 | Phyre prediction 2
Function : Show Hide

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

Interactions (From UniProt)

With
Entry
IntAct
Exp
HGS
A0A0S2Z4Q4
EBI-394632, EBI-16429135
3
MED1
Q15648
EBI-394632, EBI-394459
4
MED26
O95402
EBI-394632, EBI-394392
6
env
P03383
EBI-394632, EBI-9676086
3
HGS
O14964
EBI-394632, EBI-740220
4
MED10
Q9BTT4
EBI-394632, EBI-394354
5