Sequence Browser (O60658-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
829

Isoforms (From UniProt)

Isoform
Remark
Ref
O60658-3
May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
VSP_041675 VSP_041677
O60658-1  
O60658-2
VSP_004597
O60658-6
No experimental confirmation available.
VSP_046017
O60658-4
May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
VSP_041674 VSP_041676
O60658-5
May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available.
VSP_041678 VSP_041679
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
RACNSVFTALENSEDAI → SMQILHLKQQWAISQVN
212 - 228
splice variant
Missing
229 - 829
splice variant
Missing
239 - 284
splice variant
Missing
273 - 829
mutagenesis site
RR → AA
454 - 455
mutagenesis site
Y → F
748
sequence conflict
H → R
344
splice variant
Missing
1 - 72
splice variant
ACNSVFTALENSEDAIEIT → SGKEFTMQKRKTEIIYNKM
213 - 231
splice variant
Missing
232 - 829
splice variant
YANPAFETTMGYQSGELIGKELGEVPINEKKADL → PCCSSSWFGAAHIPSSAPVEVGVGLLPSWSLRRT
239 - 272
sequence variant
E → G
112
mutagenesis site
EY → AA
460 - 461
sequence conflict
L → V
55
sequence conflict
I → V
399

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A
Primary Accession:
O60658
Other Accessions:
B3KXE6, H0YMZ7, Q6P9H3, Q969I1, Q96PC9, Q96PD0, Q96PD1, Q96T71, Q9UMB7, Q9UMC3
Gene :
PDE8A*
Organism :
Human
Entry Name :
PDE8A_HUMAN
Length :
829
Mass (Da) :
93,304
Last modified :
19-Jan-2002
Version :
v2
Isoforms :
6 
Variants :
15 
Interactions :
0 
Structures :
Experimental 2 | Phyre prediction 7
Function : Show Hide

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes (PubMed:18983167). May be involved in maintaining basal levels of the cyclic nucleotide and/or in the cAMP regulation of germ cell development (PubMed:18983167). Binding to RAF1 reduces RAF1 'Ser-259' inhibitory-phosphorylation and stimulates RAF1-dependent EGF-activated ERK-signaling (PubMed:23509299). Protects against cell death induced by hydrogen peroxide and staurosporine (PubMed:23509299).

Interactions (From UniProt)

No interactions reported for this protein.