Sequence Browser (O95817-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
575

Isoforms (From UniProt)

Isoform
Remark
Ref
O95817-1  
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
sequence variant
R → W
71
sequence variant
I → F
94
sequence variant
C → R
151
sequence variant
P → L
209
sequence variant
R → W
258
sequence variant
P → S
380
sequence variant
P → L
407
sequence variant
L → P
462
sequence variant
R → H
477
mutagenesis site
RR → AA
480 - 481
sequence conflict
Q → R
237
sequence variant
R → Q
71
sequence variant
P → L
77
sequence variant
P → S
115
sequence variant
A → T
155
sequence variant
R → W
218
sequence variant
D → N
300
sequence variant
A → V
405
sequence variant
E → K
455
sequence variant
V → M
468
sequence variant
E → D
553
sequence conflict
Q → K
227
sequence conflict
Missing
304

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
BAG family molecular chaperone regulator 3
Other Names:
Bcl-2-associated athanogene 3, Bcl-2-binding protein Bis, Docking protein CAIR-1
Primary Accession:
O95817
Other Accessions:
A8K5L8, Q3B763, Q9NT20, Q9P120
Gene :
BAG3*, synonyms (BIS)
Organism :
Human
Entry Name :
BAG3_HUMAN
Length :
575
Mass (Da) :
61,595
Last modified :
11-Jan-2001
Version :
v3
Isoforms :
1 
Variants :
23 
Interactions :
15 
Structures :
Experimental 0 | Phyre prediction 4
Function : Show Hide

Co-chaperone for HSP70 and HSC70 chaperone proteins. Acts as a nucleotide-exchange factor (NEF) promoting the release of ADP from the HSP70 and HSC70 proteins thereby triggering client/substrate protein release. Nucleotide release is mediated via its binding to the nucleotide-binding domain (NBD) of HSPA8/HSC70 where as the substrate release is mediated via its binding to the substrate-binding domain (SBD) of HSPA8/HSC70 (PubMed:9873016, PubMed:27474739). Has anti-apoptotic activity (PubMed:10597216). Plays a role in the HSF1 nucleocytoplasmic transport (PubMed:26159920).

Interactions (From UniProt)

With
Entry
IntAct
Exp
Q96BE0
EBI-747185, EBI-9356686
2
DAZAP2
Q15038
EBI-747185, EBI-724310
8
HSPB1
P04792
EBI-747185, EBI-352682
6
LITAF
Q99732
EBI-747185, EBI-725647
7
MAGED1
Q9Y5V3
EBI-747185, EBI-716006
5
SF3B4
Q15427
EBI-747185, EBI-348469
7
STUB1
Q9UNE7
EBI-747185, EBI-357085
3
TP53BP2
Q05BL1
EBI-747185, EBI-11952721
4
ARRDC3
Q96B67
EBI-747185, EBI-2875665
7
HSPA8
Q96IS6
EBI-747185, EBI-10289199
3
HSPB8
Q9UJY1
EBI-747185, EBI-739074
8
LRRK2
Q5S007
EBI-747185, EBI-5323863
2
PDE9A
O76083
EBI-747185, EBI-742764
3
SQSTM1
Q13501
EBI-747185, EBI-307104
3
TINF2
Q9BSI4
EBI-747185, EBI-717399
2