Sequence Browser (P08833-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
259

Isoforms (From UniProt)

Isoform
Remark
Ref
P08833-1  
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Variants (From UniProt)

Type
Variation
Position
sequence variant
V → I
183
sequence conflict
H → Q
213
sequence variant
H → D
114
sequence variant
I → M
253

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Protein Information (From UniProt)

Protein:
Insulin-like growth factor-binding protein 1
Other Names:
Placental protein 12
Primary Accession:
P08833
Other Accessions:
A4D2F4, D3DVL9, Q8IYP5
Gene :
IGFBP1*, synonyms (IBP1)
Organism :
Human
Entry Name :
IBP1_HUMAN
Length :
259
Mass (Da) :
27,904
Last modified :
01-Jan-1988
Version :
v1
Isoforms :
1 
Variants :
4 
Interactions :
2 
Structures :
Experimental 3 | Phyre prediction 3
Function : Show Hide

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.

Interactions (From UniProt)

With
Entry
IntAct
Exp
FAM20C
Q8IXL6
EBI-13646303, EBI-7147442
2
IGF1
P05019
EBI-13646303, EBI-7902275
2