Sequence Browser (P16860-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
134

Isoforms (From UniProt)

Isoform
Remark
Ref
P16860-1  
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Variants (From UniProt)

Type
Variation
Position
sequence variant
R → H
47
sequence variant
R → L
25
sequence variant
M → L
93

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Protein Information (From UniProt)

Protein:
Natriuretic peptides B
Other Names:
Gamma-brain natriuretic peptide
Primary Accession:
P16860
Other Accessions:
B0ZBE9, Q6FGY0, Q9P2Q7
Gene :
NPPB*
Organism :
Human
Entry Name :
ANFB_HUMAN
Length :
134
Mass (Da) :
14,726
Last modified :
01-Jan-1990
Version :
v1
Isoforms :
1 
Variants :
3 
Interactions :
5 
Structures :
Experimental 2 | Phyre prediction 1
Function : Show Hide

Cardiac hormone which may function as a paracrine antifibrotic factor in the heart. Also plays a key role in cardiovascular homeostasis through natriuresis, diuresis, vasorelaxation, and inhibition of renin and aldosterone secretion. Specifically binds and stimulates the cGMP production of the NPR1 receptor. Binds the clearance receptor NPR3.

Interactions (From UniProt)

With
Entry
IntAct
Exp
KRTAP10-9
P60411
EBI-747044, EBI-10172052
3
PSMA3
P25788
EBI-747044, EBI-348380
3
KRT40
Q6A162
EBI-747044, EBI-10171697
3
NOTCH2NL
Q7Z3S9
EBI-747044, EBI-945833
3
SERTAD3
Q9UJW9
EBI-747044, EBI-748621
4