Sequence Browser (Q07912-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
1038

Isoforms (From UniProt)

Isoform
Remark
Ref
Q07912-1  
Q07912-2
No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
VSP_008655 VSP_008656
Q07912-3
No experimental confirmation available.
VSP_037284 VSP_037285 VSP_037286
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
M → MLEARPPRTQGSDAAGAAAGRGLRALLLSLTAAAGIWGSMGERSAYQRLAGGEEGPQRLGGGRM
1
splice variant
K → KREPPPRPPQPAFFTQ
514
splice variant
Missing
965 - 994
sequence variant
K → R
71
sequence variant
R → W
99
sequence variant
E → K
346
sequence variant
P → S
507
sequence variant
P → L
725
sequence variant
P → L
802
mutagenesis site
L → Q
120
mutagenesis site
L → Q
197
mutagenesis site
L → F
487
sequence conflict
TRTFSHASDTWMFGVTLWEMFTYGQEPWIGLNGSQILHKIDKEGERLPR → PPWRDISASSSTQFPHAVPCFPTSLLAKLLLRHSVPASSREIKLVSILC
304 - 352
sequence conflict
A → P
586
sequence conflict
PRA → AG
838 - 840
splice variant
LYLGNPMDPPDLLSVELSTSRPPQHLGGVKKPTYDPVSEDQDPL → CPFSAFSPGHPPAETCGQVLWTGRREACASDPRLHPVSSRTKGL
485 - 528
splice variant
Missing
529 - 1038
sequence variant
R → L
34
sequence variant
R → Q
99
sequence variant
T → M
152
sequence variant
M → I
409
sequence variant
V → M
638
sequence variant
R → Q
748
sequence variant
R → H
1038
mutagenesis site
K → R
158
mutagenesis site
V → R
365
sequence conflict
G → V
138
sequence conflict
Missing
353 - 1038
sequence conflict
Missing
722

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Activated CDC42 kinase 1
Other Names:
Tyrosine kinase non-receptor protein 2
Primary Accession:
Q07912
Other Accessions:
Q6ZMQ0, Q8N6U7, Q96H59
Gene :
TNK2*, synonyms (ACK1)
Organism :
Human
Entry Name :
ACK1_HUMAN
Length :
1,038
Mass (Da) :
114,569
Last modified :
05-Jan-2009
Version :
v3
Isoforms :
3 
Variants :
29 
Interactions :
9 
Structures :
Experimental 10 | Phyre prediction 5
Function : Show Hide

Non-receptor tyrosine-protein and serine/threonine-protein kinase that is implicated in cell spreading and migration, cell survival, cell growth and proliferation. Transduces extracellular signals to cytosolic and nuclear effectors. Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in trafficking and clathrin-mediated endocytosis through binding to epidermal growth factor receptor (EGFR) and clathrin. Binds to both poly- and mono-ubiquitin and regulates ligand-induced degradation of EGFR, thereby contributing to the accumulation of EGFR at the limiting membrane of early endosomes. Downstream effector of CDC42 which mediates CDC42-dependent cell migration via phosphorylation of BCAR1. May be involved both in adult synaptic function and plasticity and in brain development. Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-287'. Phosphorylates MCF2, thereby enhancing its activity as a guanine nucleotide exchange factor (GEF) toward Rho family proteins. Contributes to the control of AXL receptor levels. Confers metastatic properties on cancer cells and promotes tumor growth by negatively regulating tumor suppressor such as WWOX and positively regulating pro-survival factors such as AKT1 and AR. Phosphorylates WASP (PubMed:20110370).

Interactions (From UniProt)

With
Entry
IntAct
Exp
AQP1
P29972
EBI-603457, EBI-745213
3
CDC42
P60953-2
EBI-603457, EBI-287394
2
GALT
P07902
EBI-603457, EBI-750827
3
NOTCH2NL
Q7Z3S9
EBI-603457, EBI-945833
3
Itself
EBI-603457, EBI-603457
2
BCAR1
P56945
EBI-603457, EBI-702093
5
CLTC
Q00610
EBI-603457, EBI-354967
2
NEK6
Q9HC98
EBI-603457, EBI-740364
3
SH2D1A
O60880
EBI-11994780, EBI-6983382
3