Sequence Browser (P01019-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
485

Isoforms (From UniProt)

Isoform
Remark
Ref
P01019-1  
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
sequence variant
E → K
98
sequence variant
T → M
137
sequence variant
T → I
242
sequence variant
M → I
268
sequence variant
Y → C
281
sequence variant
R → Q
375
sequence conflict
C → S
51
sequence conflict
Q → E
333
sequence variant
L → F
43
sequence variant
G → C
114
sequence variant
T → M
207
sequence variant
L → R
244
sequence variant
M → T
268
sequence variant
P → S
335
sequence variant
L → M
392
sequence conflict
N → D
58

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Angiotensinogen
Other Names:
Serpin A8
Primary Accession:
P01019
Other Accessions:
Q16358, Q16359, Q96F91
Gene :
AGT*, synonyms (SERPINA8)
Organism :
Human
Entry Name :
ANGT_HUMAN
Length :
485
Mass (Da) :
53,154
Last modified :
21-Jan-1986
Version :
v1
Isoforms :
1 
Variants :
16 
Interactions :
5 
Structures :
Experimental 14 | Phyre prediction 3
Function : Show Hide

Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.

Angiotensin-2: acts directly on vascular smooth muscle as a potent vasoconstrictor, affects cardiac contractility and heart rate through its action on the sympathetic nervous system, and alters renal sodium and water absorption through its ability to stimulate the zona glomerulosa cells of the adrenal cortex to synthesize and secrete aldosterone.

Angiotensin-3: stimulates aldosterone release.

Angiotensin 1-7: is a ligand for the G-protein coupled receptor MAS1. Has vasodilator and antidiuretic effects. Has an antithrombotic effect that involves MAS1-mediated release of nitric oxide from platelets.

Interactions (From UniProt)

With
Entry
IntAct
Exp
AGTR1
P30556
EBI-6622938, EBI-6623016
2
AGTR2
P50052
EBI-2927577, EBI-1748067
2
REN
P00797
EBI-751728, EBI-715794
2
Agtr1
P25095
EBI-751728, EBI-764979
10
Ance
Q10714
EBI-751728, EBI-115736
2