Sequence Browser (O15105-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
426

Isoforms (From UniProt)

Isoform
Remark
Ref
O15105-2
No experimental confirmation available.
VSP_045197
O15105-1  
O15105-3
No experimental confirmation available.
VSP_047540
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
Missing
1 - 215
mutagenesis site
K → A
64
mutagenesis site
Missing
207 - 211
mutagenesis site
Missing
409 - 426
splice variant
Missing
223
mutagenesis site
K → A
70
mutagenesis site
Y → A
211
sequence conflict
G → C
71

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Mothers against decapentaplegic homolog 7
Other Names:
Mothers against decapentaplegic homolog 8, SMAD family member 7
Primary Accession:
O15105
Other Accessions:
B7Z773, K7EQ10, O14740, Q6DK23
Gene :
SMAD7*, synonyms (MADH7, MADH8)
Organism :
Human
Entry Name :
SMAD7_HUMAN
Length :
426
Mass (Da) :
46,426
Last modified :
01-Jan-1998
Version :
v1
Isoforms :
3 
Variants :
8 
Interactions :
10 
Structures :
Experimental 7 | Phyre prediction 4
Function : Show Hide

Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Interactions (From UniProt)

With
Entry
IntAct
Exp
AXIN1
O15169
EBI-3861591, EBI-710484
8
FKBP1A
P62942
EBI-3861591, EBI-1027571
3
Rnf111
Q99ML9
EBI-3861591, EBI-646015
2
SMURF2
Q9HAU4
EBI-3861591, EBI-396727
7
YAP1
P46937
EBI-3861591, EBI-1044059
7
ACVR1B
P36896
EBI-3861591, EBI-1384128
2
COPS5
Q92905
EBI-3861591, EBI-594661
10
NEDD4L
Q96PU5-5
EBI-3861591, EBI-7196393
3
SMURF1
Q9HCE7-1
EBI-3861591, EBI-15884081
4
WWP2
O00308
EBI-3861591, EBI-743923
5