Sequence Browser (O15105-2)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
426

Isoforms (From UniProt)

Isoform
Remark
Ref
O15105-2  
No experimental confirmation available.
VSP_045197
O15105-1
O15105-3
No experimental confirmation available.
VSP_047540
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3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
Mothers against decapentaplegic homolog 7
Other Names:
Mothers against decapentaplegic homolog 8, SMAD family member 7
Primary Accession:
O15105
Other Accessions:
B7Z773, K7EQ10, O14740, Q6DK23
Gene :
SMAD7*, synonyms (MADH7, MADH8)
Organism :
Human
Entry Name :
SMAD7_HUMAN
Length :
426
Mass (Da) :
46,426
Last modified :
01-Jan-1998
Version :
v1
Isoforms :
3 
Structures :
Experimental 0 | Phyre prediction 2
Function : Show Hide

Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.