PhyreRisk

Sequence Browser (P23497-1)

sequence info goes here

Available Structures (Graph-View Mode)

UniProt (Ref Seq)

Displayed Structure

Experimental Tertiary/Complex (PDB:XRay/EM)

Experimental Tertiary/Complex (PDB:NMR)

Modelled Tertiary (Phyre)

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879

To download any of the 3D structure coordinate files, right click on it → select 'Download Structure [xxx]'.

Isoforms (From UniProt)

Isoform

Remark

Ref

P23497-5

VSP_005982 VSP_005983

P23497-7

No experimental confirmation available.

VSP_045868 VSP_005978 VSP_005979

P23497-6

No experimental confirmation available.

VSP_045869 VSP_045870 VSP_005978 VSP_005979

P23497-1

P23497-2

Major isoform.

VSP_005978 VSP_005979

P23497-3

Ref.2 (AAC50743) sequence is in conflict in position: 686:M->T.

VSP_005980 VSP_005981

P23497-4

Ref.4 (AAK51202) sequence is in conflict in position: 826:M->T.

VSP_005984

Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type

Variation

Position

splice variant

MAGGGGDLSTRRLNECISPVANEMNHLPAHSHDLQR → M

1 - 36

splice variant

Missing

428 - 430

splice variant

Missing

473 - 879

splice variant

Missing

481 - 879

splice variant

Missing

689 - 879

sequence variant

M → V

433

sequence variant

E → G

699

mutagenesis site

L → A

168

sequence conflict

S → P

247

sequence conflict

A → R

651

splice variant

Missing

11 - 35

splice variant

RFSSSDFSDLSNGEELQETCSSSL → LKKKKKKKQCHPQPQPQRGLLEQS

449 - 472

splice variant

SQP → KED

478 - 480

splice variant

RILE → VMIK

685 - 688

splice variant

EEHKKKNPDASVKFSEFLKKCSETWKTIFAKEKGKFEDMAKADKAHYEREMKTYIPPKGEKKKKFKDPNAPKRPPLAFFLFCSEYRPKIKGEHPGLSIDDVVKKLAGMWNNTAAADKQFYEKKAAKLKEKYKKDIAAYRAKGKPNSAKKRVVKAEKSKKKKEEEEDEEDEQEEENEEDDDK → PENSNICEVCNKWGRLFCCDTCPRSFHEHCHIPSVEANKNPWSCIFCRIKTIQERCPESQSGHQESEVLMRQMLPEEQLKCEFLLLKVYCDSKSCFFASEPYYNREGSQGPQKPMWLNKVKTSLNEQMYTRVEGFVQDMRLIFHNHKEFYREDKFTRLGIQVQDIFEKNFRNIFAIQETSKNIIMFI

699 - 879

sequence variant

S → P

471

mutagenesis site

R → A

165

sequence conflict

R → M

sequence conflict

Q → H

402

3D Structure Viewer - JSMol

3D Structure Information placeholder

To analyse the structural impact of your missense variant:

Select the corresponding experimental/modelled structure from the "Available Structures" Panel.
Right-click on the target structure and download it.
Go to our web server Missense3D to analyse structural impact.

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Protein Information (From UniProt)

Protein:

Nuclear autoantigen Sp-100

Other Names:

Nuclear dot-associated Sp100 protein, Speckled 100 kDa

Primary Accession:

P23497

Other Accessions:

B4DDX5, B8ZZD8, E7EUA7, E9PH61, F8WFE2, O75450, Q13343, Q8TE34, Q96F70, Q96T24, Q96T95, Q9NP33, Q9UE32

Gene :

SP100*

Organism :

Human

Entry Name :

SP100_HUMAN

Length :

879

Mass (Da) :

100,417

Last modified :

27-Jan-2001

Version :

Isoforms :

Variants :

Interactions :

Structures :

Experimental 120 | Phyre prediction 4

Function : Show Hide

Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.

Interactions (From UniProt)

With

Entry

IntAct

Exp

Q59GP6

EBI-751145, EBI-10243413

AMOTL2

Q9Y2J4-4

EBI-751145, EBI-10187270

CBX5

P45973

EBI-6589365, EBI-78219

DYRK2

Q92630

EBI-751145, EBI-749432

GIPC2

Q8TF65

EBI-751145, EBI-712067

L3MBTL3

Q96JM7

EBI-751145, EBI-2686809

RTP5

Q14D33

EBI-751145, EBI-10217913

SUMO3

P55854

EBI-751145, EBI-474067

UL123

P03169

EBI-751145, EBI-6691147

ACTN2

P35609

EBI-751145, EBI-77797

CASP8AP2

Q9UKL3

EBI-751145, EBI-2339650

DNMT3A

Q9Y6K1

EBI-751145, EBI-923653

ETS1

P14921

EBI-751145, EBI-913209

HEL25

V9HWG0

EBI-751145, EBI-10183977

RBM39

Q14498-3

EBI-751145, EBI-6654703

SUMO1

P63165

EBI-751145, EBI-80140

TRAF3IP3

Q9Y228

EBI-751145, EBI-765817

ZC2HC1A

Q96GY0

EBI-751145, EBI-5458880

Method	X-ray
PDB	5PXL
Chain	A/B
Res (�)	1.35
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5FB0
Chain	A/C
Res (�)	2.7
Coverage	696 - 878
Length	182

Method	NMR
PDB	1H5P
Chain	A
Coverage	595 - 688
Length	93

Method	Phyre
Template	1H5P_A
E-Value	4e-24
Confidence	99.8
Estimated TM	0.977
Coverage	595 - 686
Length	91

Method	X-ray
PDB	6G5P
Chain	A/B
Res (�)	1.35
Coverage	466 - 508
Length	42

UniProt	P23497
Gene	SP100
Mass (Da)	100417
Organism	Human
Length	879 (1 - 879)

Method	X-ray
PDB	5FB1
Chain	A
Res (�)	2.1
Coverage	696 - 875
Length	179

Method	X-ray
PDB	5PWS
Chain	A/B
Res (�)	1.4
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PXT
Chain	A/B
Res (�)	1.4
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PX2
Chain	A/B
Res (�)	1.43
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PX6
Chain	A/B
Res (�)	1.43
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PXA
Chain	A/B
Res (�)	1.43
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PXN
Chain	A/B
Res (�)	1.43
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PWU
Chain	A/B
Res (�)	1.44
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PY5
Chain	A/B
Res (�)	1.44
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PX4
Chain	A/B
Res (�)	1.45
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PYW
Chain	A/B
Res (�)	1.45
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PWG
Chain	A/B
Res (�)	1.46
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PWR
Chain	A/B
Res (�)	1.46
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PXB
Chain	A/B
Res (�)	1.46
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PWF
Chain	A/B
Res (�)	1.48
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PXS
Chain	A/B
Res (�)	1.49
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PWH
Chain	A/B
Res (�)	1.5
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PWP
Chain	A/B
Res (�)	1.51
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PXC
Chain	A/B
Res (�)	1.52
Coverage	466 - 508
Length	42

Sequence Browser (P23497-1)

Sequence Viewer Preferences

Available Structures (Graph-View Mode)

Isoforms (From UniProt)

Variants (From UniProt)

3D Structure Viewer - JSMol

To analyse the structural impact of your missense variant:

Protein Information (From UniProt)

Interactions (From UniProt)

Method	X-ray
PDB	5PZ8
Chain	A/B
Res (�)	1.52
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PWQ
Chain	A/B
Res (�)	1.52
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PYL
Chain	A/B
Res (�)	1.53
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PWM
Chain	A/B
Res (�)	1.54
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PZ7
Chain	A/B
Res (�)	1.54
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PX0
Chain	A/B
Res (�)	1.55
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PXE
Chain	A/B
Res (�)	1.55
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PYA
Chain	A/B
Res (�)	1.55
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PX1
Chain	A/B
Res (�)	1.55
Coverage	466 - 508
Length	42

Method	X-ray
PDB	5PX3
Chain	A/B
Res (�)	1.57
Coverage	466 - 508
Length	42