Sequence Browser (P23497-4)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
If the whole structure is coloured grey in '3D Structure Viewer' panel, please click the icon - on the top left corner of the viewer.
(If nothing changes then 'Sequence ↔ Structure' mapping may be unavailable).
1
879

Isoforms (From UniProt)

Isoform
Remark
Ref
P23497-5
VSP_005982 VSP_005983
P23497-7
No experimental confirmation available.
VSP_045868 VSP_005978 VSP_005979
P23497-6
No experimental confirmation available.
VSP_045869 VSP_045870 VSP_005978 VSP_005979
P23497-1
P23497-2
Major isoform.
VSP_005978 VSP_005979
P23497-3
Ref.2 (AAC50743) sequence is in conflict in position: 686:M->T.
VSP_005980 VSP_005981
P23497-4  
Ref.4 (AAK51202) sequence is in conflict in position: 826:M->T.
VSP_005984
Click on Isoform of interest to be redirected to the corresponding page

3D Structure Viewer - JSMol  

To analyse the structural impact of your missense variant:

  • Select the corresponding experimental/modelled structure from the "Available Structures" Panel.
  • Right-click on the target structure and download it.
  • Go to our web server Missense3D to analyse structural impact.

    • Go to Missense3D

Protein Information (From UniProt)

Protein:
Nuclear autoantigen Sp-100
Other Names:
Nuclear dot-associated Sp100 protein, Speckled 100 kDa
Primary Accession:
P23497
Other Accessions:
B4DDX5, B8ZZD8, E7EUA7, E9PH61, F8WFE2, O75450, Q13343, Q8TE34, Q96F70, Q96T24, Q96T95, Q9NP33, Q9UE32
Gene :
SP100*
Organism :
Human
Entry Name :
SP100_HUMAN
Length :
879
Mass (Da) :
100,417
Last modified :
27-Jan-2001
Version :
v3
Isoforms :
7 
Structures :
Experimental 0 | Phyre prediction 3
Function : Show Hide

Together with PML, this tumor suppressor is a major constituent of the PML bodies, a subnuclear organelle involved in a large number of physiological processes including cell growth, differentiation and apoptosis. Functions as a transcriptional coactivator of ETS1 and ETS2 according to PubMed:11909962. Under certain conditions, it may also act as a corepressor of ETS1 preventing its binding to DNA according to PubMed:15247905. Through the regulation of ETS1 it may play a role in angiogenesis, controlling endothelial cell motility and invasion. Through interaction with the MRN complex it may be involved in the regulation of telomeres lengthening. May also regulate TP53-mediated transcription and through CASP8AP2, regulate FAS-mediated apoptosis. Also plays a role in infection by viruses, including human cytomegalovirus and Epstein-Barr virus, through mechanisms that may involve chromatin and/or transcriptional regulation.