Sequence Browser (Q06609-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
339

Isoforms (From UniProt)

Isoform
Remark
Ref
Q06609-2
No experimental confirmation available.
VSP_005556
Q06609-3
Mutagenesis of Arg-264 to Ala inhibits nuclear localization. Mutagenesis of Lys-264 to Gln inhibits nuclear localization. Deletion of 254-Arg-Lys-255 inhibits nuclear localization.
VSP_041724 VSP_041725
Q06609-1  
Q06609-4
No experimental confirmation available.
VSP_043655
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
AEAAKLVPMGFTTATEFHQRRSEIIQITTGSKELDKLLQ → TESRSVARLECNSVILVYCTLRLSGSSDSPASASRVVGTT
76 - 114
splice variant
Missing
77 - 173
splice variant
FGVAVVITNQVVAQVDGAAMFAADPK → IVSEERKRGNQNLQNLRLSLSS
259 - 284
splice variant
Missing
285 - 339
sequence variant
T → P
131
sequence variant
R → Q
150
sequence variant
A → T
293
mutagenesis site
K → R
58
mutagenesis site
K → R
64
mutagenesis site
F → A
86
mutagenesis site
A → E
89
mutagenesis site
SA → LE
208 - 209
mutagenesis site
T → A
309
sequence conflict
K → Q
313

3D Structure Viewer - JSMol  

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Protein Information (From UniProt)

Protein:
DNA repair protein RAD51 homolog 1
Other Names:
RAD51 homolog A
Primary Accession:
Q06609
Other Accessions:
B0FXP0, B2R8T6, Q6FHX9, Q6ZNA8, Q9BV60
Gene :
RAD51*, synonyms (RAD51A, RECA)
Organism :
Human
Entry Name :
RAD51_HUMAN
Length :
339
Mass (Da) :
36,966
Last modified :
01-Jan-1994
Version :
v1
Isoforms :
4 
Variants :
14 
Interactions :
17 
Structures :
Experimental 7 | Phyre prediction 2
Function : Show Hide

Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:28575658). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed:26253028).

Interactions (From UniProt)

With
Entry
IntAct
Exp
Itself
EBI-297202, EBI-297202
8
BRCA2
P51587
EBI-297202, EBI-79792
45
CHEK1
O14757
EBI-297202, EBI-974488
3
FAM84B
Q96KN1
EBI-297202, EBI-9057780
4
IL24
Q13007
EBI-297202, EBI-3915542
2
MDC1
Q14676
EBI-297202, EBI-495644
3
NAT2
P11245
EBI-297202, EBI-9057228
4
NSD3
Q9BZ95
EBI-297202, EBI-3390132
4
PALB2
Q86YC2
EBI-297202, EBI-1222653
7
POLQ
O75417-1
EBI-297202, EBI-16141065
3
RAD51AP1
Q96B01-2
EBI-297202, EBI-1178743
6
RAD51AP1
Q96B01-3
EBI-297202, EBI-1178748
6
RAD51C
O43502
EBI-297202, EBI-2267048
6
RAD52
P43351
EBI-297202, EBI-706448
3
SWSAP1
Q6NVH7
EBI-297202, EBI-5281637
2
TP53
P04637
EBI-297202, EBI-366083
2
XRCC3
O43542
EBI-297202, EBI-2849976
3