Sequence Browser (Q06609-4)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
339

Isoforms (From UniProt)

Isoform
Remark
Ref
Q06609-1
Q06609-4  
No experimental confirmation available.
VSP_043655
Q06609-2
No experimental confirmation available.
VSP_005556
Q06609-3
Mutagenesis of Arg-264 to Ala inhibits nuclear localization. Mutagenesis of Lys-264 to Gln inhibits nuclear localization. Deletion of 254-Arg-Lys-255 inhibits nuclear localization.
VSP_041724 VSP_041725
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Protein Information (From UniProt)

Protein:
DNA repair protein RAD51 homolog 1
Other Names:
RAD51 homolog A
Primary Accession:
Q06609
Other Accessions:
B0FXP0, B2R8T6, Q6FHX9, Q6ZNA8, Q9BV60
Gene :
RAD51*, synonyms (RAD51A, RECA)
Organism :
Human
Entry Name :
RAD51_HUMAN
Length :
339
Mass (Da) :
36,966
Last modified :
01-Jan-1994
Version :
v1
Isoforms :
4 
Structures :
Experimental 0 | Phyre prediction 2
Function : Show Hide

Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR) (PubMed:28575658). Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange (PubMed:26681308). Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair (PubMed:26253028).