Sequence Browser (Q12800-1)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
If the whole structure is coloured grey in '3D Structure Viewer' panel, please click the icon - on the top left corner of the viewer.
(If nothing changes then 'Sequence ↔ Structure' mapping may be unavailable).
1
502

Isoforms (From UniProt)

Isoform
Remark
Ref
Q12800-2
VSP_017647 VSP_017648
Q12800-1  
Q12800-3
VSP_017647
Q12800-4
VSP_017648
Click on Isoform of interest to be redirected to the corresponding page

Variants (From UniProt)

Type
Variation
Position
splice variant
Missing
189 - 239
mutagenesis site
V → E
211
mutagenesis site
Q → L
234
sequence conflict
G → A
92
sequence conflict
A → Q
491
splice variant
Missing
491
mutagenesis site
I → R
213
mutagenesis site
K → E
236
sequence conflict
T → M
249

3D Structure Viewer - JSMol  

To analyse the structural impact of your missense variant:

  • Select the corresponding experimental/modelled structure from the "Available Structures" Panel.
  • Right-click on the target structure and download it.
  • Go to our web server Missense3D to analyse structural impact.

    • Go to Missense3D

Protein Information (From UniProt)

Protein:
Alpha-globin transcription factor CP2
Other Names:
SAA3 enhancer factor, Transcription factor LSF
Primary Accession:
Q12800
Other Accessions:
A8K5E9, Q12801, Q9UD75, Q9UD77
Gene :
TFCP2*, synonyms (LSF, SEF)
Organism :
Human
Entry Name :
TFCP2_HUMAN
Length :
502
Mass (Da) :
57,256
Last modified :
21-Jan-2006
Version :
v2
Isoforms :
4 
Variants :
9 
Interactions :
54 
Structures :
Experimental 0 | Phyre prediction 3
Function : Show Hide

Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.

Interactions (From UniProt)

With
Entry
IntAct
Exp
ADPRH
P54922
EBI-717422, EBI-6657604
3
BAG6
P46379
EBI-717422, EBI-347552
3
CA1
P00915
EBI-717422, EBI-3912102
6
CAPN3
P20807-2
EBI-717422, EBI-16433991
3
CCDC94
Q9BW85
EBI-717422, EBI-10300345
5
DNAJC27
Q9NZQ0
EBI-717422, EBI-10317544
5
DPH1
Q9BZG8
EBI-717422, EBI-10303200
3
EAF1
Q96JC9
EBI-717422, EBI-769261
3
EPHA10
Q5JZY3-3
EBI-717422, EBI-10244652
3
FANCL
Q9NW38
EBI-717422, EBI-2339898
3
ASAP3
Q8TDY4
EBI-717422, EBI-2609717
3
C19orf73
Q9NVV2
EBI-717422, EBI-2859285
3
CAPN3
A0A0S2Z3E6
EBI-717422, EBI-16430532
3
CBX8
Q9HC52
EBI-717422, EBI-712912
5
CDC73
Q6P1J9
EBI-717422, EBI-930143
8
DNAJC5B
Q9UF47
EBI-717422, EBI-10320535
3
E2F8
A0AVK6
EBI-717422, EBI-7779316
3
EIF5B
Q8N5A0
EBI-717422, EBI-6137508
3
ESR2
Q92731-3
EBI-717422, EBI-12259414
3
FARS2
O95363
EBI-717422, EBI-2513774
3
GPANK1
O95872
EBI-717422, EBI-751540
3
MOB3C
Q70IA8
EBI-717422, EBI-9679267
3
MORF4L1
Q9UBU8-2
EBI-717422, EBI-10288852
3
MRPL40
Q9NQ50
EBI-717422, EBI-1053902
3
NPEPL1
Q8NDH3-4
EBI-717422, EBI-10269715
3
PHF21B
A0A0S2Z615
EBI-717422, EBI-16434035
3
PITPNM1
O00562
EBI-717422, EBI-2861268
3
POLL
Q9UGP5-2
EBI-717422, EBI-10320765
3
PPIG
Q13427
EBI-717422, EBI-396072
3
PPP3R2
Q96LZ3
EBI-717422, EBI-3906025
3
RBMS1
P29558
EBI-717422, EBI-5462600
3
SDCBP
O00560
EBI-717422, EBI-727004
3
STMN2
Q93045
EBI-717422, EBI-714194
3
TCEA2
Q15560
EBI-717422, EBI-710310
3
TRAPPC12
Q53QD4
EBI-717422, EBI-10242701
3
UBE2I
P63279
EBI-717422, EBI-80168
4
ZCCHC12
Q6PEW1
EBI-717422, EBI-748373
6
FBXL18
Q96D16
EBI-717422, EBI-744419
3
IRAK1BP1
Q5VVH5
EBI-717422, EBI-9658404
3
MORF4L1
Q9UBU8
EBI-717422, EBI-399246
3
MRPL11
Q9Y3B7
EBI-717422, EBI-5453723
3
NABP1
Q96AH0
EBI-717422, EBI-2889252
3
PHF1
O43189
EBI-717422, EBI-530034
4
PIMREG
Q9BSJ6
EBI-717422, EBI-2568609
3
PLCB1
Q9NQ66
EBI-717422, EBI-3396023
3
POLR3GL
Q9BT43
EBI-717422, EBI-2855862
3
PPP1R1B
Q9UD71
EBI-717422, EBI-722119
3
PSMD5
Q16401
EBI-717422, EBI-752143
3
RXRB
P28702-3
EBI-717422, EBI-16429492
3
SHTN1
A0MZ66-7
EBI-717422, EBI-10171490
3
SUMO1
P63165
EBI-717422, EBI-80140
3
TDRD1
Q9BXT4-2
EBI-717422, EBI-10301451
3
TSPAN12
O95859
EBI-717422, EBI-2466403
3
ZCCHC10
Q8TBK6
EBI-717422, EBI-597063
3