Sequence Browser (Q12800-3)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
If the whole structure is coloured grey in '3D Structure Viewer' panel, please click the icon - on the top left corner of the viewer.
(If nothing changes then 'Sequence ↔ Structure' mapping may be unavailable).
1
502

Isoforms (From UniProt)

Isoform
Remark
Ref
Q12800-2
VSP_017647 VSP_017648
Q12800-1
Q12800-3  
VSP_017647
Q12800-4
VSP_017648
Click on Isoform of interest to be redirected to the corresponding page

3D Structure Viewer - JSMol  

To analyse the structural impact of your missense variant:

  • Select the corresponding experimental/modelled structure from the "Available Structures" Panel.
  • Right-click on the target structure and download it.
  • Go to our web server Missense3D to analyse structural impact.

    • Go to Missense3D

Protein Information (From UniProt)

Protein:
Alpha-globin transcription factor CP2
Other Names:
SAA3 enhancer factor, Transcription factor LSF
Primary Accession:
Q12800
Other Accessions:
A8K5E9, Q12801, Q9UD75, Q9UD77
Gene :
TFCP2*, synonyms (LSF, SEF)
Organism :
Human
Entry Name :
TFCP2_HUMAN
Length :
502
Mass (Da) :
57,256
Last modified :
21-Jan-2006
Version :
v2
Isoforms :
4 
Structures :
Experimental 0 | Phyre prediction 3
Function : Show Hide

Binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with UBP1 (By similarity). Functions as part of the SSP (stage selector protein) complex. Facilitates the interaction of the gamma-globin genes with enhancer elements contained in the locus control region in fetal erythroid cells. Interacts by binding to the stage selector element (SSE) in the proximal gamma-globin promoter.