Sequence Browser (Q13535-2)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
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1
2644
Isoform
Remark
Ref
No experimental confirmation available.
VSP_036907 VSP_036908
Q13535-2  
VSP_013305 VSP_013304
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Protein:
Other Names:
Ataxia telangiectasia and Rad3-related protein, FRAP-related protein 1
Primary Accession:
Other Accessions:
Q59HB2, Q7KYL3, Q93051, Q9BXK4
Gene :
ATR*, synonyms (FRP1)
Organism :
Human
Entry Name :
Length :
2,644
Mass (Da) :
301,367
Last modified :
05-Jan-2004
Version :
v3
Isoforms :
3 
Structures :
Experimental 0 | Phyre prediction 0

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.