Sequence Browser (Q13535-2)

Available Structures (Graph-View Mode)

UniProt (Ref Seq)
Displayed Structure
Experimental Tertiary/Complex (PDB:XRay/EM)
Experimental Tertiary/Complex (PDB:NMR)
Modelled Tertiary (Phyre)
If the whole structure is coloured grey in '3D Structure Viewer' panel, please click the icon - on the top left corner of the viewer.
(If nothing changes then 'Sequence ↔ Structure' mapping may be unavailable).
1
2644

Isoforms (From UniProt)

Isoform
Remark
Ref
Q13535-1
Q13535-3
No experimental confirmation available.
VSP_036907 VSP_036908
Q13535-2  
VSP_013305 VSP_013304
Click on Isoform of interest to be redirected to the corresponding page

3D Structure Viewer - JSMol  

3D Structure Display

By clicking on any PDB entry under the 'Available Structures' section, you can visualise in this panel, the 3D details about the protein, and also see information about it's interactions and mutations where available.

To analyse the structural impact of your missense variant:

  • Select the corresponding experimental/modelled structure from the "Available Structures" Panel.
  • Right-click on the target structure and download it.
  • Go to our web server Missense3D to analyse structural impact.

    • Go to Missense3D

Protein Information (From UniProt)

Protein:
Serine/threonine-protein kinase ATR
Other Names:
Ataxia telangiectasia and Rad3-related protein, FRAP-related protein 1
Primary Accession:
Q13535
Other Accessions:
Q59HB2, Q7KYL3, Q93051, Q9BXK4
Gene :
ATR*, synonyms (FRP1)
Organism :
Human
Entry Name :
ATR_HUMAN
Length :
2,644
Mass (Da) :
301,367
Last modified :
05-Jan-2004
Version :
v3
Isoforms :
3 
Structures :
Experimental 0 | Phyre prediction 0
Function : Show Hide

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.